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MGP000570

UniProt Annotations

Entry Information
Gene Namecreatine kinase, mitochondrial 1B
Protein EntryKCRU_HUMAN
UniProt IDP12532
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P12532-1; Sequence=Displayed; Name=2; IsoId=P12532-2; Sequence=VSP_038045;
Catalytic ActivityATP + creatine = ADP + phosphocreatine. {ECO:0000255|PROSITE-ProRule:PRU10029}.
FunctionReversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
MiscellaneousMitochondrial creatine kinase binds cardiolipin.
SimilarityBelongs to the ATP:guanido phosphotransferase family. {ECO:0000255|PROSITE-ProRule:PRU00842, ECO:0000255|PROSITE- ProRule:PRU00843}.
SimilarityContains 1 phosphagen kinase C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00843}.
SimilarityContains 1 phosphagen kinase N-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00842}.
Subcellular LocationMitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
SubunitExists as an octamer composed of four MTCK homodimers. {ECO:0000269|PubMed:10737943}.
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