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MGP000578

UniProt Annotations

Entry Information

Gene Name	chloride channel accessory 1
Protein Entry	CLCA1_HUMAN
UniProt ID	A8K7I4
Species	Human

Comments

Comment type	Description
Domain	The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA Substrates. {ECO:0000269\|PubMed:23112050}.
Function	May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. {ECO:0000269\|PubMed:11445004, ECO:0000269\|PubMed:11842292, ECO:0000269\|PubMed:11956057, ECO:0000269\|PubMed:23112050, ECO:0000269\|PubMed:9828122}.
Induction	By IL13/interleukin-13 in tracheobronchial epithelial cells. Up-regulated by histamine in a dose-dependent manner. Significantly down-regulated in colorectal cancer. Significantly up-regulated in the IL9-responsive mucus-producing epithelium of asthmatic patients. Significantly decreased in nasal polyp. Significantly increased by TNF in upper airway mucosa. {ECO:0000269\|PubMed:11445004, ECO:0000269\|PubMed:11842292, ECO:0000269\|PubMed:11956057, ECO:0000269\|PubMed:15696080, ECO:0000269\|PubMed:16012037, ECO:0000269\|PubMed:16151054, ECO:0000269\|PubMed:17622767}.
Ptm	Glycosylated. {ECO:0000269\|PubMed:9828122}.
Ptm	The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. {ECO:0000269\|PubMed:23112050, ECO:0000269\|PubMed:9828122}.
Similarity	Belongs to the CLCR family. {ECO:0000305}.
Similarity	Contains 1 VWFA domain. {ECO:0000255\|PROSITE- ProRule:PRU00219}.
Subcellular Location	Secreted, extracellular space {ECO:0000269\|PubMed:15919655}. Cell membrane {ECO:0000269\|PubMed:15919655}; Peripheral membrane protein {ECO:0000269\|PubMed:15919655}; Extracellular side {ECO:0000269\|PubMed:15919655}. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
Tissue Specificity	Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus- producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in. {ECO:0000269\|PubMed:10437792, ECO:0000269\|PubMed:11842292, ECO:0000269\|PubMed:11956057, ECO:0000269\|PubMed:16012037, ECO:0000269\|PubMed:9828122}.