MGP Database

MGP000614

Ontology/Pathway Information

Entrez Gene ID	1277
Gene Name	collagen, type I, alpha 1
Gene Symbol	COL1A1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005584	IMP:UniProtKB	C	collagen type I trimer
GO:0005788	TAS:Reactome	C	endoplasmic reticulum lumen
GO:0031012	IDA:UniProtKB	C	extracellular matrix
GO:0005576	TAS:Reactome	C	extracellular region
GO:0005615	IDA:BHF-UCL	C	extracellular space
GO:0005794	IEA:Ensembl	C	Golgi apparatus
GO:0030141	IEA:Ensembl	C	secretory granule
GO:0005201	IEA:Ensembl	F	extracellular matrix structural constituent
GO:0042802	IDA:UniProtKB	F	identical protein binding
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0048407	IDA:MGI	F	platelet-derived growth factor binding
GO:0007596	TAS:Reactome	P	blood coagulation
GO:0001568	IMP:UniProtKB	P	blood vessel development
GO:0060346	IEA:Ensembl	P	bone trabecula formation
GO:0060351	IEA:Ensembl	P	cartilage development involved in endochondral bone morphogenesis
GO:0071230	IEA:Ensembl	P	cellular response to amino acid stimulus
GO:0071364	IEA:Ensembl	P	cellular response to epidermal growth factor stimulus
GO:0044344	IEA:Ensembl	P	cellular response to fibroblast growth factor stimulus
GO:1902618	IEA:Ensembl	P	cellular response to fluoride
GO:0071260	IEA:Ensembl	P	cellular response to mechanical stimulus
GO:0071300	IEA:Ensembl	P	cellular response to retinoic acid
GO:0071560	IEA:Ensembl	P	cellular response to transforming growth factor beta stimulus
GO:0071356	IEA:Ensembl	P	cellular response to tumor necrosis factor
GO:0071306	IEA:Ensembl	P	cellular response to vitamin E
GO:0032964	IMP:UniProtKB	P	collagen biosynthetic process
GO:0030574	TAS:Reactome	P	collagen catabolic process
GO:0030199	IMP:UniProtKB	P	collagen fibril organization
GO:0048706	IMP:UniProtKB	P	embryonic skeletal system development
GO:0001958	IEA:Ensembl	P	endochondral ossification
GO:0022617	TAS:Reactome	P	extracellular matrix disassembly
GO:0030198	TAS:Reactome	P	extracellular matrix organization
GO:0060325	IEA:Ensembl	P	face morphogenesis
GO:0001957	IEA:Ensembl	P	intramembranous ossification
GO:0050900	TAS:Reactome	P	leukocyte migration
GO:0010812	IEA:Ensembl	P	negative regulation of cell-substrate adhesion
GO:0001649	IEA:Ensembl	P	osteoblast differentiation
GO:0030168	TAS:Reactome	P	platelet activation
GO:0090263	IDA:UniProtKB	P	positive regulation of canonical Wnt signaling pathway
GO:0030335	IDA:UniProtKB	P	positive regulation of cell migration
GO:0010718	IDA:UniProtKB	P	positive regulation of epithelial to mesenchymal transition
GO:0045893	IDA:UniProtKB	P	positive regulation of transcription, DNA-templated
GO:0070208	IEA:Ensembl	P	protein heterotrimerization
GO:0034504	IDA:UniProtKB	P	protein localization to nucleus
GO:0015031	IEA:Ensembl	P	protein transport
GO:0051591	IEA:Ensembl	P	response to cAMP
GO:0031960	IEA:Ensembl	P	response to corticosteroid
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0042542	IEA:Ensembl	P	response to hydrogen peroxide
GO:0055093	IEA:Ensembl	P	response to hyperoxia
GO:0043434	IEA:Ensembl	P	response to peptide hormone
GO:0007605	IMP:UniProtKB	P	sensory perception of sound
GO:0001501	IMP:UniProtKB	P	skeletal system development
GO:0043589	IMP:UniProtKB	P	skin morphogenesis
GO:0044691	IEA:Ensembl	P	tooth eruption
GO:0034505	IMP:UniProtKB	P	tooth mineralization
GO:0007601	IMP:UniProtKB	P	visual perception

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_150268	Anchoring fibril formation
REACT_150180	Assembly of collagen fibrils and other multimeric structures
REACT_160300	Binding and Uptake of Ligands by Scavenger Receptors
REACT_12051	Cell surface interactions at the vascular wall
REACT_121139	Collagen biosynthesis and modifying enzymes
REACT_150401	Collagen degradation
REACT_120729	Collagen formation
REACT_150206	Crosslinking of collagen fibrils
REACT_118572	Degradation of the extracellular matrix
REACT_163906	ECM proteoglycans
REACT_118779	Extracellular matrix organization
REACT_1695	GPVI-mediated activation cascade
REACT_604	Hemostasis
REACT_13552	Integrin cell surface interactions
REACT_163874	Non-integrin membrane-ECM interactions
REACT_798	Platelet activation, signaling and aggregation
REACT_1230	Platelet Adhesion to exposed collagen
REACT_163699	Scavenging by Class A Receptors
REACT_163942	Syndecan interactions

SMP Pathway Links

SMP ID	Description
SMP00269	Acenocoumarol Action Pathway
SMP00280	Alteplase Action Pathway
SMP00286	Aminocaproic Acid Action Pathway
SMP00281	Anistreplase Action Pathway
SMP00288	Aprotinin Action Pathway
SMP00275	Ardeparin Action Pathway
SMP00276	Argatroban Action Pathway
SMP00277	Bivalirudin Action Pathway
SMP00586	Coagulation
SMP00656	Dicoumarol Action Pathway
SMP00270	Dicumarol Action Pathway
SMP00272	Enoxaparin Action Pathway
SMP00273	Fondaparinux Action Pathway
SMP00274	Heparin Action Pathway
SMP00278	Lepirudin Action Pathway
SMP00655	Phenindione Action Pathway
SMP00271	Phenprocoumon Action Pathway
SMP00285	Reteplase Action Pathway
SMP00282	Streptokinase Action Pathway
SMP00283	Tenecteplase Action Pathway
SMP00287	Tranexamic Acid Action Pathway
SMP00284	Urokinase Action Pathway
SMP00268	Warfarin Action Pathway
SMP00279	Ximelagatran Action Pathway