MGP Database

MGP000616

Ontology/Pathway Information

Entrez Gene ID	1280
Gene Name	collagen, type II, alpha 1
Gene Symbol	COL2A1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005604	IEA:Ensembl	C	basement membrane
GO:0005585	IDA:BHF-UCL	C	collagen type II trimer
GO:0005788	TAS:Reactome	C	endoplasmic reticulum lumen
GO:0031012	IDA:UniProtKB	C	extracellular matrix
GO:0005576	TAS:Reactome	C	extracellular region
GO:0005615	IEA:Ensembl	C	extracellular space
GO:0030020	IC:BHF-UCL	F	extracellular matrix structural constituent conferring tensile strength
GO:0042802	NAS:BHF-UCL	F	identical protein binding
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0048407	IDA:MGI	F	platelet-derived growth factor binding
GO:0007411	TAS:Reactome	P	axon guidance
GO:0001502	IEA:Ensembl	P	cartilage condensation
GO:0051216	TAS:BHF-UCL	P	cartilage development
GO:0060351	IEA:Ensembl	P	cartilage development involved in endochondral bone morphogenesis
GO:0071773	IEA:Ensembl	P	cellular response to BMP stimulus
GO:0007417	IEA:Ensembl	P	central nervous system development
GO:0002062	IEA:Ensembl	P	chondrocyte differentiation
GO:0030574	TAS:Reactome	P	collagen catabolic process
GO:0030199	IMP:BHF-UCL	P	collagen fibril organization
GO:0060272	IMP:BHF-UCL	P	embryonic skeletal joint morphogenesis
GO:0001958	IEA:Ensembl	P	endochondral ossification
GO:0022617	TAS:Reactome	P	extracellular matrix disassembly
GO:0030198	TAS:Reactome	P	extracellular matrix organization
GO:0003007	IEA:Ensembl	P	heart morphogenesis
GO:0042472	IEA:Ensembl	P	inner ear morphogenesis
GO:0060174	IEA:Ensembl	P	limb bud formation
GO:2001240	IEA:Ensembl	P	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0030903	IEA:Ensembl	P	notochord development
GO:0071599	IEA:Ensembl	P	otic vesicle development
GO:0060021	IEA:Ensembl	P	palate development
GO:0006029	IEA:Ensembl	P	proteoglycan metabolic process
GO:0010468	IEA:Ensembl	P	regulation of gene expression
GO:0007605	IMP:BHF-UCL	P	sensory perception of sound
GO:0001501	IMP:BHF-UCL	P	skeletal system development
GO:0001894	IEA:Ensembl	P	tissue homeostasis
GO:0007601	IMP:UniProtKB	P	visual perception

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_150180	Assembly of collagen fibrils and other multimeric structures
REACT_18266	Axon guidance
REACT_121139	Collagen biosynthesis and modifying enzymes
REACT_150401	Collagen degradation
REACT_120729	Collagen formation
REACT_118572	Degradation of the extracellular matrix
REACT_111045	Developmental Biology
REACT_163906	ECM proteoglycans
REACT_118779	Extracellular matrix organization
REACT_13552	Integrin cell surface interactions
REACT_18312	NCAM1 interactions
REACT_18334	NCAM signaling for neurite out-growth
REACT_163874	Non-integrin membrane-ECM interactions
REACT_16888	Signaling by PDGF
REACT_111102	Signal Transduction