MGP Database

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MGP000639

UniProt Annotations

Entry Information
Gene Namecollagen, type XV, alpha 1
Protein EntryCOFA1_HUMAN
UniProt IDP39059
SpeciesHuman
Comments
Comment typeDescription
CautionThe name restin has also been used for CAP-Gly domain- containing linker protein 1 the product of the CLIP1 gene. {ECO:0000305}.
FunctionRestin potently inhibits angiogenesis. {ECO:0000250}.
FunctionStructural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. {ECO:0000269|PubMed:10049780}.
PtmO-glycosylated; with core 1 or possibly core 8 glycans. An N- terminal peptide contains chondroitin sulfate. {ECO:0000269|PubMed:10791950, ECO:0000269|PubMed:22171320}.
PtmProlines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
SimilarityBelongs to the multiplexin collagen family. {ECO:0000305}.
SimilarityContains 1 laminin G-like domain. {ECO:0000305}.
SimilarityContains 4 collagen-like domains. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space, extracellular matrix {ECO:0000250}.
SubunitTrimer; disulfide-linked. {ECO:0000269|PubMed:15698950}.
Tissue SpecificityExpressed predominantly in internal organs such as adrenal gland, pancreas and kidney.
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