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MGP Database

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MGP000640

UniProt Annotations

Entry Information

Gene Name	collagen, type XVI, alpha 1
Protein Entry	COGA1_HUMAN
UniProt ID	Q07092
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q07092-1; Sequence=Displayed; Name=2; IsoId=Q07092-2; Sequence=VSP_024259, VSP_024260; Note=No experimental confirmation available.;
Developmental Stage	Transiently elevated expression during gestation, and decrease at term.
Domain	This sequence defines eighteen different domains, nine triple-helical domains (COL9 to COL1) and ten non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule either elastic or flexible.
Function	Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology. {ECO:0000269\|PubMed:16754661}.
Ptm	Glycosylated. {ECO:0000269\|PubMed:15165854, ECO:0000269\|PubMed:7882999}.
Ptm	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Similarity	Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. {ECO:0000305}.
Similarity	Contains 1 laminin G-like domain. {ECO:0000305}.
Similarity	Contains 8 collagen-like domains. {ECO:0000305}.
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000269\|PubMed:9022684}.
Subunit	Homotrimer. Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3. {ECO:0000269\|PubMed:15165854, ECO:0000269\|PubMed:16754661, ECO:0000269\|PubMed:7882999, ECO:0000269\|PubMed:9022684}.
Tissue Specificity	In papillary dermis, is a component of specialized fibrillin-1-containing microfibrils, whereas in territorial cartilage matrix, it is localized to a discrete population of thin, weakly banded collagen fibrils in association with other collagens (at protein level). In the placenta, where it is found in the amnion, a membranous tissue lining the amniotic cavity. Within the amnion, it is found in an acellular, relatively dense layer of a complex network of reticular fibers. Also located to a fibroblast layer beneath this dense layer. Exists in tissues in association with other types of collagen. {ECO:0000269\|PubMed:12782140}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/COL16A1ID44542ch1p35.html";