MGP Database

MGP000644

Ontology/Pathway Information

Entrez Gene ID	1312
Gene Name	catechol-O-methyltransferase
Gene Symbol	COMT
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0030424	IEA:Ensembl	C	axon
GO:0044297	IEA:Ensembl	C	cell body
GO:0005829	TAS:Reactome	C	cytosol
GO:0043197	IEA:Ensembl	C	dendritic spine
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0016020	IDA:UniProtKB	C	membrane
GO:0005739	IEA:Ensembl	C	mitochondrion
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0045211	IEA:Ensembl	C	postsynaptic membrane
GO:0016206	IEA:UniProtKB-EC	F	catechol O-methyltransferase activity
GO:0000287	IEA:InterPro	F	magnesium ion binding
GO:0008171	TAS:ProtInc	F	O-methyltransferase activity
GO:0016036	IEA:Ensembl	P	cellular response to phosphate starvation
GO:0032502	IEA:Ensembl	P	developmental process
GO:0042420	IEA:Ensembl	P	dopamine catabolic process
GO:0008210	IEA:Ensembl	P	estrogen metabolic process
GO:0007565	IEA:Ensembl	P	female pregnancy
GO:0007612	IEA:Ensembl	P	learning
GO:0032259	TAS:Reactome	P	methylation
GO:0048609	IEA:Ensembl	P	multicellular organismal reproductive process
GO:0045963	IEA:Ensembl	P	negative regulation of dopamine metabolic process
GO:0035814	IEA:Ensembl	P	negative regulation of renal sodium excretion
GO:0048662	IEA:Ensembl	P	negative regulation of smooth muscle cell proliferation
GO:0042136	TAS:Reactome	P	neurotransmitter biosynthetic process
GO:0042135	IEA:UniProtKB-KW	P	neurotransmitter catabolic process
GO:0050668	IEA:Ensembl	P	positive regulation of homocysteine metabolic process
GO:0051930	IEA:Ensembl	P	regulation of sensory perception of pain
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0014070	IEA:Ensembl	P	response to organic cyclic compound
GO:0048265	IEA:Ensembl	P	response to pain
GO:0007614	IEA:Ensembl	P	short-term memory
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0007268	TAS:Reactome	P	synaptic transmission
GO:0006805	TAS:Reactome	P	xenobiotic metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_13433	Biological oxidations
REACT_268587	Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
REACT_268321	Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
REACT_268129	Defective GGT1 causes Glutathionuria (GLUTH)
REACT_267887	Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
REACT_268063	Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
REACT_268256	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
REACT_267818	Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
REACT_268027	Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
REACT_268058	Defective UGT1A1 causes hyperbilirubinemia
REACT_268618	Defective UGT1A4 causes hyperbilirubinemia
REACT_116125	Disease
REACT_15514	Dopamine clearance from the synaptic cleft
REACT_15548	Enzymatic degradation of dopamine by COMT
REACT_15511	Enzymatic degradation of Dopamine by monoamine oxidase
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_111217	Metabolism
REACT_6946	Methylation
REACT_13685	Neuronal System
REACT_13583	Neurotransmitter Clearance In The Synaptic Cleft
REACT_6959	Phase II conjugation
REACT_13477	Transmission across Chemical Synapses

SMP Pathway Links

SMP ID	Description
SMP00169	Alkaptonuria
SMP00429	Disulfiram Action Pathway
SMP00498	Dopamine beta-hydroxylase deficiency
SMP00190	Hawkinsinuria
SMP00533	Monoamine oxidase-a deficiency (MAO-A)
SMP00327	Phenytoin (Antiarrhythmic) Action Pathway
SMP00006	Tyrosine Metabolism
SMP00494	Tyrosinemia, transient, of the newborn
SMP00218	Tyrosinemia Type I