MGP Database

MGP000662

Record overview

MGPD ID	MGP000662
Gene ID	1360
Species	Homo sapiens (Human)
Gene Name	carboxypeptidase B1 (tissue)
Gene Symbol	CPB1
Synonyms	CPB; PASP; PCPB;
Alternate names	carboxypeptidase B; protaminase; procarboxypeptidase B; pancreas-specific protein; tissue carboxypeptidase B; pancreatic carboxypeptidase B;
Chromosome	3
Map Location	3q24
EC Number	3.4.17.2
Summary	Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for CPB1

Proteins

carboxypeptidase B preproprotein

Refseq ID:	NP_001862
Protein GI:	54607080
UniProt ID:	P15086
mRNA ID:	NM_001871
Length:	417
RefSeq Status:

MLALLVLVTVALASAHHGGEHFEGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNV
VEAQFDSRVRATGHSYEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGRE
IQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAY
LTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEE
TFLAIKYVASYVLEHLY

sig_peptide: 1..15
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1485
peptide sequence: 
MLALLVLVTVALASA

mat_peptide: 111..417
product: carboxypeptidase B
calculated_mol_wt: 34848
peptide sequence: 
ATGHSYEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLDKL
DFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAYLTIHSYSQMM
IYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVAS
YVLEHLY