MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000664

UniProt Annotations

Entry Information
Gene Namecarboxypeptidase D
Protein EntryCBPD_HUMAN
UniProt IDO75976
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75976-1; Sequence=Displayed; Name=2; IsoId=O75976-2; Sequence=VSP_045833, VSP_045834; Note=No experimental confirmation available.;
Biophysicochemical PropertiespH dependence: Optimum pH is 6.0-6.5.;
Catalytic ActivityReleases C-terminal Arg and Lys from polypeptides.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
DomainThere are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.
SimilarityBelongs to the peptidase M14 family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue SpecificityHighly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.
  logo