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MGP000665

UniProt Annotations

Entry Information
Gene Namecarboxypeptidase E
Protein EntryCBPE_HUMAN
UniProt IDP16870
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P16870-1; Sequence=Displayed; Name=2; Synonyms=CPE delta-N; IsoId=P16870-2; Sequence=VSP_040959;
Catalytic ActivityRelease of C-terminal arginine or lysine residues from polypeptides.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
FunctionRemoves residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
InteractionQ13131:PRKAA1; NbExp=1; IntAct=EBI-711320, EBI-1181405;
Sequence CautionSequence=BAG52254.1; Type=Frameshift; Positions=415; Evidence={ECO:0000305};
SimilarityBelongs to the peptidase M14 family. {ECO:0000305}.
Subcellular LocationIsoform 1: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000250}.
Subcellular LocationIsoform 2: Nucleus.
SubunitIsoform 2 interacts with HDAC1 and HDAC2. {ECO:0000269|PubMed:21285511}.
Tissue SpecificityIsoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas. {ECO:0000269|PubMed:21285511}.
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