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MGP000667

Record overview

MGPD IDMGP000667
Gene ID1365
SpeciesHomo sapiens (Human)
Gene Nameclaudin 3
Gene Symbol CLDN3
SynonymsRVP1; HRVP1; C7orf1; CPE-R2; CPETR2;
Alternate namesclaudin-3; CPE-R 2; CPE-receptor 2; ventral prostate.1-like protein; ventral prostate.1 protein homolog; Clostridium perfringens enterotoxin receptor 2;
Chromosome7
Map Location7q11.23
SummaryTight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CLDN3

Proteins

claudin-3
Refseq ID:NP_001297
Protein GI:4502875
UniProt ID:O15551
mRNA ID:NM_001306
Length:220
RefSeq Status:
MSMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVG
AQCTNCVQDDTAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPREKKYTATKVVYSA
PRSTGPGASLGTGYDRKDYV
 
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