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MGP000678

UniProt Annotations

Entry Information
Gene Namecarnitine O-acetyltransferase
Protein EntryCACP_HUMAN
UniProt IDP43155
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=SM-1400; IsoId=P43155-1; Sequence=Displayed; Name=2; Synonyms=SM-1200; IsoId=P43155-2; Sequence=VSP_000792; Note=No experimental confirmation available.; Name=3; IsoId=P43155-3; Sequence=VSP_012798;
Catalytic ActivityAcetyl-CoA + carnitine = CoA + O- acetylcarnitine.
FunctionCarnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
SimilarityBelongs to the carnitine/choline acetyltransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum {ECO:0000305}. Peroxisome {ECO:0000305}. Mitochondrion inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Subcellular LocationIsoform 1: Mitochondrion {ECO:0000305}.
Subcellular LocationIsoform 2: Peroxisome {ECO:0000305}.
SubunitMonomer. {ECO:0000269|PubMed:12562770, ECO:0000269|PubMed:15099582}.
Tissue SpecificityMostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney.
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