MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000679

Ontology/Pathway Information

Entrez Gene ID1385
Gene NamecAMP responsive element binding protein 1
Gene Symbol CREB1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005719 IDA:BHF-UCLCnuclear euchromatin
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:HPACnucleus
GO:0005667 IEA:EnsemblCtranscription factor complex
GO:0035497 IDA:BHF-UCLFcAMP response element binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0001102 IPI:BHF-UCLFRNA polymerase II activating transcription factor binding
GO:0000978 IDA:NTNU_SBFRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IC:NTNU_SBFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0000980 IDA:BHF-UCLFRNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003705 IDA:BHF-UCLFRNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0001190 IDA:BHF-UCLFRNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003700 IDA:MGIFsequence-specific DNA binding transcription factor activity
GO:0003712 TAS:ProtIncFtranscription cofactor activity
GO:0007202 TAS:ReactomePactivation of phospholipase C activity
GO:0007411 TAS:ReactomePaxon guidance
GO:0071294 IEA:EnsemblPcellular response to zinc ion
GO:0007623 ISS:UniProtKBPcircadian rhythm
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0007595 IEA:EnsemblPlactation
GO:0060430 IEA:EnsemblPlung saccule development
GO:0007613 IEA:EnsemblPmemory
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0010944 IDA:BHF-UCLPnegative regulation of transcription by competitive promoter binding
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0021983 IEA:EnsemblPpituitary gland development
GO:0045600 ISS:UniProtKBPpositive regulation of fat cell differentiation
GO:0046887 IEA:EnsemblPpositive regulation of hormone secretion
GO:0046889 ISS:UniProtKBPpositive regulation of lipid biosynthetic process
GO:0040018 IEA:EnsemblPpositive regulation of multicellular organism growth
GO:0045672 IEA:EnsemblPpositive regulation of osteoclast differentiation
GO:0045893 ISS:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:NTNU_SBPpositive regulation of transcription from RNA polymerase II promoter
GO:0006468 IDA:MGIPprotein phosphorylation
GO:0050821 ISS:UniProtKBPprotein stabilization
GO:0008361 IEA:EnsemblPregulation of cell size
GO:0042493 IEA:EnsemblPresponse to drug
GO:0033762 ISS:UniProtKBPresponse to glucagon
GO:0010033 IDA:MGIPresponse to organic substance
GO:0033363 IEA:EnsemblPsecretory granule organization
GO:0007165 TAS:ReactomePsignal transduction
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0006366 IDA:GOCPtranscription from RNA polymerase II promoter
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
GO:0060509 IEA:EnsemblPType I pneumocyte differentiation
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_75774Adaptive Immune System
REACT_12442AKT phosphorylates targets in the nucleus
REACT_18266Axon guidance
REACT_15307Ca-dependent events
REACT_9000Calmodulin induced events
REACT_15502CaMK IV-mediated phosphorylation of CREB
REACT_9053CaM pathway
REACT_24941Circadian Clock
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_12524CREB phosphorylation
REACT_20625CREB phosphorylation through the activation of Adenylate Cyclase
REACT_20642CREB phosphorylation through the activation of CaMKII
REACT_20661CREB phosphorylation through the activation of CaMKK
REACT_20568CREB phosphorylation through the activation of Ras
REACT_111064DAG and IP3 signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_15526G-protein mediated events
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_21308MAP kinase activation in TLR cascade
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_264351Mitochondrial biogenesis
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_18334NCAM signaling for neurite out-growth
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_163910NOTCH2 intracellular domain regulates transcription
REACT_12433Nuclear Events (kinase and transcription factor activation)
REACT_15295Opioid Signalling
REACT_264135Organelle biogenesis and maintenance
REACT_21310Phospholipase C-mediated cascade
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_15497PKA-mediated phosphorylation of CREB
REACT_15426PLC beta mediated events
REACT_115720PLCG1 events in ERBB2 signaling
REACT_12079PLC-gamma1 signalling
REACT_20593Post NMDA receptor activation events
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_299Signaling by NOTCH
REACT_118721Signaling by NOTCH2
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_264212Transcriptional activation of mitochondrial biogenesis
REACT_13477Transmission across Chemical Synapses
REACT_25281TRIF-mediated TLR3/TLR4 signaling
SMP Pathway Links
SMP IDDescription
SMP00309Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
SMP00312Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
SMP00311Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
SMP00333Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
SMP00335Intracellular Signalling Through Histamine H2 Receptor and Histamine
SMP00338Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
  logo