MGP Database

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MGP000696

UniProt Annotations

Entry Information
Gene Namecolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Protein EntryIL3RB_HUMAN
UniProt IDP32927
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P32927-1; Sequence=Displayed; Name=2; IsoId=P32927-2; Sequence=VSP_032798;
DiseasePulmonary surfactant metabolism dysfunction 5 (SMDP5) [MIM:614370]: A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid- Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. {ECO:0000269|PubMed:21075760}. Note=The disease is caused by mutations affecting the gene represented in this entry.
DomainThe box 1 motif is required for JAK interaction and/or activation.
DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.
FunctionHigh affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
InteractionP04141:CSF2; NbExp=2; IntAct=EBI-1809771, EBI-1809826; P05113:IL5; NbExp=2; IntAct=EBI-1809771, EBI-2435811; P05556:ITGB1; NbExp=5; IntAct=EBI-1809771, EBI-703066; O60674:JAK2; NbExp=4; IntAct=EBI-1809771, EBI-518647;
PtmMay be phosphorylated by LYN. {ECO:0000250}.
SimilarityBelongs to the type I cytokine receptor family. Type 4 subfamily. {ECO:0000305}.
SimilarityContains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to- head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2. Interacts with LYN (By similarity). {ECO:0000250}.
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