MGP Database

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MGP000718

Ontology/Pathway Information

Entrez Gene ID1491
Gene Namecystathionine gamma-lyase
Gene Symbol CTH
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005634 IDA:HPACnucleus
GO:0016846 TAS:ReactomeFcarbon-sulfur lyase activity
GO:0004123 IDA:UniProtKBFcystathionine gamma-lyase activity
GO:0047982 TAS:ReactomeFhomocysteine desulfhydrase activity
GO:0080146 TAS:ReactomeFL-cysteine desulfhydrase activity
GO:0044540 IMP:UniProtKBFL-cystine L-cysteine-lyase (deaminating)
GO:0030170 IDA:UniProtKBFpyridoxal phosphate binding
GO:0034641 TAS:ReactomePcellular nitrogen compound metabolic process
GO:0019344 IDA:UniProtKBPcysteine biosynthetic process
GO:0006534 TAS:ProtIncPcysteine metabolic process
GO:0030968 TAS:UniProtKBPendoplasmic reticulum unfolded protein response
GO:0070814 IDA:UniProtKBPhydrogen sulfide biosynthetic process
GO:2001234 IEA:EnsemblPnegative regulation of apoptotic signaling pathway
GO:0043123 IEA:EnsemblPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092 IEA:EnsemblPpositive regulation of NF-kappaB transcription factor activity
GO:0051289 IPI:UniProtKBPprotein homotetramerization
GO:0018272 IDA:UniProtKBPprotein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0044524 IMP:UniProtKBPprotein sulfhydration
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0000098 TAS:ReactomePsulfur amino acid catabolic process
GO:0000096 TAS:ReactomePsulfur amino acid metabolic process
GO:0019346 TAS:ReactomePtranssulfuration
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_115589Cysteine formation from homocysteine
REACT_115654Degradation of cysteine and homocysteine
REACT_111217Metabolism
REACT_13Metabolism of amino acids and derivatives
REACT_115639Sulfur amino acid metabolism
SMP Pathway Links
SMP IDDescription
SMP007213-Phosphoglycerate dehydrogenase deficiency
SMP00499Beta-mercaptolactate-cysteine disulfiduria
SMP00177Cystathionine Beta-Synthase Deficiency
SMP00013Cysteine Metabolism
SMP00722Cystinosis, ocular nonnephropathic
SMP00179Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
SMP00242Dimethylglycine Dehydrogenase Deficiency
SMP00484Dimethylglycinuria
SMP00514Gamma-cystathionase deficiency (CTH)
SMP00004Glycine and Serine Metabolism
SMP00222Glycine N-methyltransferase Deficiency
SMP00455Homocysteine Degradation
SMP00515Homocystinuria, cystathionine beta-synthase deficiency
SMP00570Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type
SMP00485Hyperglycinemia, non-ketotic
SMP00341Hypermethioninemia
SMP00221Methionine Adenosyltransferase Deficiency
SMP00033Methionine Metabolism
SMP00340Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
SMP00223Non Ketotic Hyperglycinemia
SMP00214S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
SMP00244Sarcosinemia
SMP00029Selenoamino Acid Metabolism
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