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MGP000721

UniProt Annotations

Entry Information
Gene Namecatenin (cadherin-associated protein), alpha 2
Protein EntryCTNA2_HUMAN
UniProt IDP26232
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=1; Synonyms=AlphaN-catenin II; IsoId=P26232-1; Sequence=Displayed; Name=2; Synonyms=AlphaN-catenin I; IsoId=P26232-2; Sequence=VSP_020337; Name=3; IsoId=P26232-3; Sequence=VSP_038009; Note=No experimental confirmation available.; Name=4; IsoId=P26232-4; Sequence=VSP_038008, VSP_020337; Name=5; IsoId=P26232-5; Sequence=VSP_038007, VSP_020337; Note=No experimental confirmation available.; Name=6; Synonyms=AlphaN-catenin III; IsoId=P26232-6; Sequence=VSP_038005, VSP_038006, VSP_020337;
FunctionMay function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250}.
SimilarityBelongs to the vinculin/alpha-catenin family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:16182284}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, axon {ECO:0000250}. Note=Recruited to the nucleus upon ZNF639 overexpression.
SubunitInteracts with ZNF639. {ECO:0000269|PubMed:16182284}.
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