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MGP000724

UniProt Annotations

Entry Information
Gene Namecatenin (cadherin-associated protein), delta 1
Protein EntryCTND1_HUMAN
UniProt IDO60716
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing, Alternative initiation; Named isoforms=32; Comment=Isoforms result of a combination of four transcription start sites and three alternatively spliced exons(A, B and C).; Name=1ABC; IsoId=O60716-1; Sequence=Displayed; Name=1AB; IsoId=O60716-2; Sequence=VSP_006743; Name=1AC; IsoId=O60716-3; Sequence=VSP_006745; Note=Contains a phosphothreonine at position 916.; Name=1BC; IsoId=O60716-4; Sequence=VSP_006744; Name=1A; IsoId=O60716-5; Sequence=VSP_006743, VSP_006745; Note=Contains a phosphothreonine at position 910.; Name=1B; IsoId=O60716-6; Sequence=VSP_006743, VSP_006744; Name=1C; IsoId=O60716-7; Sequence=VSP_006744, VSP_006745; Note=Contains a phosphothreonine at position 895.; Name=1; IsoId=O60716-8; Sequence=VSP_006743, VSP_006744, VSP_006745; Note=Contains a phosphothreonine at position 889.; Name=2ABC; IsoId=O60716-9; Sequence=VSP_006740; Name=2AB; IsoId=O60716-10; Sequence=VSP_006740, VSP_006743; Name=2AC; IsoId=O60716-11; Sequence=VSP_006740, VSP_006745; Note=Contains a phosphothreonine at position 862.; Name=2BC; IsoId=O60716-12; Sequence=VSP_006740, VSP_006744; Name=2A; IsoId=O60716-13; Sequence=VSP_006740, VSP_006743, VSP_006745; Note=Contains a phosphothreonine at position 856.; Name=2B; IsoId=O60716-14; Sequence=VSP_006740, VSP_006743, VSP_006744; Name=2C; IsoId=O60716-15; Sequence=VSP_006740, VSP_006744, VSP_006745; Note=Contains a phosphothreonine at position 841.; Name=2; IsoId=O60716-16; Sequence=VSP_006740, VSP_006743, VSP_006744, VSP_006745; Note=Contains a phosphothreonine at position 835.; Name=3ABC; IsoId=O60716-17; Sequence=VSP_006741; Name=3AB; IsoId=O60716-18; Sequence=VSP_006741, VSP_006743; Name=3AC; IsoId=O60716-19; Sequence=VSP_006741, VSP_006745; Note=Contains a phosphothreonine at position 815.; Name=3BC; IsoId=O60716-20; Sequence=VSP_006741, VSP_006744; Name=3A; IsoId=O60716-21; Sequence=VSP_006741, VSP_006743, VSP_006745; Note=Contains a phosphothreonine at position 809.; Name=3B; IsoId=O60716-22; Sequence=VSP_006741, VSP_006743, VSP_006744; Name=3C; IsoId=O60716-23; Sequence=VSP_006741, VSP_006744, VSP_006745; Note=Contains a phosphothreonine at position 794.; Name=3; IsoId=O60716-24; Sequence=VSP_006741, VSP_006743, VSP_006744, VSP_006745; Note=Contains a phosphothreonine at position 788.; Name=4ABC; IsoId=O60716-25; Sequence=VSP_006742; Name=4AB; IsoId=O60716-26; Sequence=VSP_006742, VSP_006743; Name=4AC; IsoId=O60716-27; Sequence=VSP_006742, VSP_006745; Note=Contains a phosphothreonine at position 593.; Name=4BC; IsoId=O60716-28; Sequence=VSP_006742, VSP_006744; Name=4A; IsoId=O60716-29; Sequence=VSP_006742, VSP_006743, VSP_006745; Note=Contains a phosphothreonine at position 587.; Name=4B; IsoId=O60716-30; Sequence=VSP_006742, VSP_006743, VSP_006744; Name=4C; IsoId=O60716-31; Sequence=VSP_006742, VSP_006744, VSP_006745; Note=Contains a phosphothreonine at position 572.; Name=4; IsoId=O60716-32; Sequence=VSP_006742, VSP_006743, VSP_006744, VSP_006745; Note=Contains a phosphothreonine at position 566.;
DomainA possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
DomainARM repeats 1 to 5 mediate interaction with cadherins.
FunctionBinds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. {ECO:0000250, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:20371349}.
InductionInduced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure. {ECO:0000269|PubMed:14699141}.
InteractionP09803:Cdh1 (xeno); NbExp=3; IntAct=EBI-702059, EBI-984420; P00533:EGFR; NbExp=4; IntAct=EBI-701927, EBI-297353; Q7Z6J6:FRMD5; NbExp=3; IntAct=EBI-701927, EBI-727282; Q8WY41:NANOS1; NbExp=2; IntAct=EBI-9634525, EBI-9630165; O14495:PPAP2B; NbExp=9; IntAct=EBI-701927, EBI-766232; Q12913:PTPRJ; NbExp=5; IntAct=EBI-701927, EBI-2264500;
PtmPhosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated by PTPRJ. {ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:17081983, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:17487921, ECO:0000269|PubMed:18220336, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:20564219, ECO:0000269|PubMed:21406692, ECO:0000269|PubMed:7623846}.
Sequence CautionSequence=BAA20838.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the beta-catenin family. {ECO:0000305}.
SimilarityContains 10 ARM repeats. {ECO:0000255|PROSITE- ProRule:PRU00259}.
Subcellular LocationCytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. Isoforms 4A and 1AB are excluded from the nucleus. {ECO:0000250}.
Subcellular LocationIsoform 1A: Nucleus.
Subcellular LocationIsoform 2A: Nucleus.
Subcellular LocationIsoform 3A: Nucleus.
SubunitBelongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, and gamma- catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin. Interacts with ZBTB33. Interacts with GLIS2. Interacts with NANOS1 (via N-terminal region). Interacts with FER. {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:20371349, ECO:0000269|PubMed:7623846}.
Tissue SpecificityExpressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs. {ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:14699141}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CTNND1ID40197ch11q11.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ctnnd1/";
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