MGP Database

MGP000727

Record overview

MGPD ID	MGP000727
Gene ID	1509
Species	Homo sapiens (Human)
Gene Name	cathepsin D
Gene Symbol	CTSD
Synonyms	CPSD; CLN10; HEL-S-130P;
Alternate names	cathepsin D; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; epididymis secretory sperm binding protein Li 130P;
Chromosome	11
Map Location	11p15.5
EC Number	3.4.23.5
Summary	This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for CTSD

Proteins

cathepsin D preproprotein

Refseq ID:	NP_001900
Protein GI:	4503143
UniProt ID:	P07339
mRNA ID:	NM_001909
Length:	412
RefSeq Status:

MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGS
SNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILG
MAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRD
NNRVGFAEAARL

sig_peptide: 1..18
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P07339.1)
calculated_mol_wt: 1809
peptide sequence: 
MQPSSLLPLALCLLAAPA

mat_peptide: 65..412
product: Cathepsin D
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P07339.1)
calculated_mol_wt: 37853
peptide sequence: 
GPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSAS
SASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNV
TRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKT
LCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL

mat_peptide: 65..161
product: Cathepsin D light chain (Probable)
inference: non-experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P07339.1)
calculated_mol_wt: 10680
peptide sequence: 
GPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQ

mat_peptide: 169..412
product: Cathepsin D heavy chain (Probable)
inference: non-experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P07339.1)
calculated_mol_wt: 26629
peptide sequence: 
LGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKA
YWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLS
GFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL