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MGP000729

Record overview

MGPD IDMGP000729
Gene ID1511
SpeciesHomo sapiens (Human)
Gene Namecathepsin G
Gene Symbol CTSG
SynonymsCG; CATG;
Alternate namescathepsin G;
Chromosome14
Map Location14q11.2
EC Number3.4.21.20
SummaryThe protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]
OrthologsView orthologs and multiple alignments for CTSG

Proteins

cathepsin G preproprotein
Refseq ID:NP_001902
Protein GI:4503149
UniProt ID:P08311
mRNA ID:NM_001911
Length:255
RefSeq Status:
MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQY
NQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGD
SGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1911
peptide sequence: 
MQPLLLLLAFLLPTGAEA

mat_peptide: 21..255
product: cathepsin G
experiment: DESCRIPTION:antimicrobial peptide[PMID: 2116408]
calculated_mol_wt: 26758
peptide sequence: 
IIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKS
SGVPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL
 
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