MGP Database

MGP000745

Ontology/Pathway Information

Entrez Gene ID	1543
Gene Name	cytochrome P450, family 1, subfamily A, polypeptide 1
Gene Symbol	CYP1A1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005789	TAS:Reactome	C	endoplasmic reticulum membrane
GO:0005739	IEA:Ensembl	C	mitochondrion
GO:0070330	IEA:UniProtKB-EC	F	aromatase activity
GO:0032451	IEA:Ensembl	F	demethylase activity
GO:0016711	IEA:Ensembl	F	flavonoid 3'-monooxygenase activity
GO:0020037	IEA:InterPro	F	heme binding
GO:0005506	IEA:InterPro	F	iron ion binding
GO:0016491	IDA:BHF-UCL	F	oxidoreductase activity
GO:0016679	IEA:Ensembl	F	oxidoreductase activity, acting on diphenols and related substances as donors
GO:0019825	TAS:ProtInc	F	oxygen binding
GO:0008395	IEA:Ensembl	F	steroid hydroxylase activity
GO:0070576	IDA:BHF-UCL	F	vitamin D 24-hydroxylase activity
GO:0042904	IEA:Ensembl	P	9-cis-retinoic acid biosynthetic process
GO:0007568	IEA:Ensembl	P	aging
GO:0009308	IEA:Ensembl	P	amine metabolic process
GO:0019369	TAS:Reactome	P	arachidonic acid metabolic process
GO:0043010	IEA:Ensembl	P	camera-type eye development
GO:0008283	IEA:Ensembl	P	cell proliferation
GO:0044255	TAS:Reactome	P	cellular lipid metabolic process
GO:0071407	IDA:MGI	P	cellular response to organic cyclic compound
GO:0009804	IEA:Ensembl	P	coumarin metabolic process
GO:0019341	IEA:Ensembl	P	dibenzo-p-dioxin catabolic process
GO:0048565	IEA:Ensembl	P	digestive tract development
GO:0017144	IDA:BHF-UCL	P	drug metabolic process
GO:0009792	IEA:Ensembl	P	embryo development ending in birth or egg hatching
GO:0019373	TAS:Reactome	P	epoxygenase P450 pathway
GO:0009812	IEA:Ensembl	P	flavonoid metabolic process
GO:0070365	IEA:Ensembl	P	hepatocyte differentiation
GO:0050665	IEA:Ensembl	P	hydrogen peroxide biosynthetic process
GO:0017143	IEA:Ensembl	P	insecticide metabolic process
GO:0060137	IEA:Ensembl	P	maternal process involved in parturition
GO:0097267	TAS:Reactome	P	omega-hydroxylase P450 pathway
GO:0055114	IDA:BHF-UCL	P	oxidation-reduction process
GO:0006778	IEA:Ensembl	P	porphyrin-containing compound metabolic process
GO:1900087	IEA:Ensembl	P	positive regulation of G1/S transition of mitotic cell cycle
GO:0046677	IEA:Ensembl	P	response to antibiotic
GO:0046685	IEA:Ensembl	P	response to arsenic-containing substance
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032094	IEA:Ensembl	P	response to food
GO:0009635	IEA:Ensembl	P	response to herbicide
GO:0055093	IEA:Ensembl	P	response to hyperoxia
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0035902	IEA:Ensembl	P	response to immobilization stress
GO:0010041	IEA:Ensembl	P	response to iron(III) ion
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0009624	IEA:Ensembl	P	response to nematode
GO:0009615	IEA:Ensembl	P	response to virus
GO:0033189	IEA:Ensembl	P	response to vitamin A
GO:0009611	IEA:Ensembl	P	response to wounding
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0042359	IC:BHF-UCL	P	vitamin D metabolic process
GO:0006805	TAS:Reactome	P	xenobiotic metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_147851	Arachidonic acid metabolism
REACT_13433	Biological oxidations
REACT_13567	Cytochrome P450 - arranged by substrate type
REACT_268767	Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601	Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761	Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217	Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478	Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087	Defective CYP1B1 causes Glaucoma
REACT_267893	Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803	Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108	Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734	Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413	Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633	Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491	Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326	Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441	Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709	Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486	Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863	Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528	Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125	Disease
REACT_22279	Fatty acid, triacylglycerol, and ketone body metabolism
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_111217	Metabolism
REACT_22258	Metabolism of lipids and lipoproteins
REACT_13705	Phase 1 - Functionalization of compounds
REACT_116145	PPARA activates gene expression
REACT_19241	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_150134	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
REACT_150417	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
REACT_13543	Xenobiotics

SMP Pathway Links

SMP ID	Description
SMP00063	Tryptophan Metabolism