MGP Database

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MGP000746

Ontology/Pathway Information

Entrez Gene ID1544
Gene Namecytochrome P450, family 1, subfamily A, polypeptide 2
Gene Symbol CYP1A2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0043231 IDA:UniProtKBCintracellular membrane-bounded organelle
GO:0070330 IEA:UniProtKB-ECFaromatase activity
GO:0034875 IDA:BHF-UCLFcaffeine oxidase activity
GO:0032451 IDA:UniProtKBFdemethylase activity
GO:0009055 TAS:UniProtKBFelectron carrier activity
GO:0019899 IPI:BHF-UCLFenzyme binding
GO:0020037 IDA:UniProtKBFheme binding
GO:0005506 IEA:InterProFiron ion binding
GO:0004497 IDA:BHF-UCLFmonooxygenase activity
GO:0016491 IDA:BHF-UCLFoxidoreductase activity
GO:0016712 IMP:UniProtKBFoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0009820 IDA:BHF-UCLPalkaloid metabolic process
GO:0019369 TAS:ReactomeParachidonic acid metabolic process
GO:0045333 IEA:EnsemblPcellular respiration
GO:0071276 IEA:EnsemblPcellular response to cadmium ion
GO:0018894 IEA:EnsemblPdibenzo-p-dioxin metabolic process
GO:0042737 IMP:BHF-UCLPdrug catabolic process
GO:0017144 IDA:BHF-UCLPdrug metabolic process
GO:0019373 TAS:ReactomePepoxygenase P450 pathway
GO:0042738 IDA:BHF-UCLPexogenous drug catabolic process
GO:0046483 IDA:BHF-UCLPheterocycle metabolic process
GO:0050665 IEA:EnsemblPhydrogen peroxide biosynthetic process
GO:0030324 IEA:EnsemblPlung development
GO:0032259 TAS:ReactomePmethylation
GO:0032787 IDA:BHF-UCLPmonocarboxylic acid metabolic process
GO:0016098 IDA:BHF-UCLPmonoterpenoid metabolic process
GO:0097267 TAS:ReactomePomega-hydroxylase P450 pathway
GO:0055114 IDA:BHF-UCLPoxidation-reduction process
GO:0071615 IDA:BHF-UCLPoxidative deethylation
GO:0070989 IDA:BHF-UCLPoxidative demethylation
GO:0006778 IEA:EnsemblPporphyrin-containing compound metabolic process
GO:0009791 IEA:EnsemblPpost-embryonic development
GO:0010468 IEA:EnsemblPregulation of gene expression
GO:0032355 IEA:EnsemblPresponse to estradiol
GO:0035902 IEA:EnsemblPresponse to immobilization stress
GO:0032496 IEA:EnsemblPresponse to lipopolysaccharide
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006706 IMP:BHF-UCLPsteroid catabolic process
GO:0009403 IDA:BHF-UCLPtoxin biosynthetic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264461Aflatoxin activation and detoxification
REACT_147851Arachidonic acid metabolism
REACT_13721Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_267633Defective ACY1 causes encephalopathy
REACT_268587Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_268321Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
REACT_268129Defective GGT1 causes Glutathionuria (GLUTH)
REACT_267887Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268063Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
REACT_268256Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
REACT_267818Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_268027Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
REACT_268058Defective UGT1A1 causes hyperbilirubinemia
REACT_268618Defective UGT1A4 causes hyperbilirubinemia
REACT_116125Disease
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_6946Methylation
REACT_13705Phase 1 - Functionalization of compounds
REACT_6959Phase II conjugation
REACT_150134Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
REACT_150417Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
REACT_13543Xenobiotics
SMP Pathway Links
SMP IDDescription
SMP00640Acetaminophen Metabolism Pathway
SMP00028Caffeine Metabolism
SMP00639Clomipramine Metabolism Pathway
SMP00260Clopidogrel Action Pathway
SMP00610Clopidogrel Metabolism Pathway
SMP00641Doxepin Metabolism Pathway
SMP00422Imipramine Action Pathway
SMP00625Imipramine Metabolism Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00398Lidocaine (Local Anaesthetic) Action Pathway
SMP00620Lidocaine (Local Anaesthetic) Metabolism Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
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