MGP Database

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MGP000747

Ontology/Pathway Information

Entrez Gene ID1545
Gene Namecytochrome P450, family 1, subfamily B, polypeptide 1
Gene Symbol CYP1B1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0005739 ISS:UniProtKBCmitochondrion
GO:0070330 IEA:UniProtKB-ECFaromatase activity
GO:0020037 IDA:UniProtKBFheme binding
GO:0005506 IEA:InterProFiron ion binding
GO:0004497 IDA:UniProtKBFmonooxygenase activity
GO:0016712 IDA:MGIFoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825 TAS:UniProtKBFoxygen binding
GO:0001525 IEA:EnsemblPangiogenesis
GO:0019369 IDA:UniProtKBParachidonic acid metabolic process
GO:0048514 ISS:UniProtKBPblood vessel morphogenesis
GO:0007155 ISS:UniProtKBPcell adhesion
GO:0006725 IEA:EnsemblPcellular aromatic compound metabolic process
GO:0070301 ISS:UniProtKBPcellular response to hydrogen peroxide
GO:0071407 IDA:MGIPcellular response to organic cyclic compound
GO:0030199 ISS:UniProtKBPcollagen fibril organization
GO:0071603 IEA:EnsemblPendothelial cell-cell adhesion
GO:0043542 ISS:UniProtKBPendothelial cell migration
GO:0019373 TAS:ReactomePepoxygenase P450 pathway
GO:0008210 IDA:UniProtKBPestrogen metabolic process
GO:0008631 ISS:UniProtKBPintrinsic apoptotic signaling pathway in response to oxidative stress
GO:0046466 ISS:UniProtKBPmembrane lipid catabolic process
GO:0033629 ISS:UniProtKBPnegative regulation of cell adhesion mediated by integrin
GO:0030336 ISS:UniProtKBPnegative regulation of cell migration
GO:0008285 ISS:UniProtKBPnegative regulation of cell proliferation
GO:0032088 ISS:UniProtKBPnegative regulation of NF-kappaB transcription factor activity
GO:0006809 ISS:UniProtKBPnitric oxide biosynthetic process
GO:0097267 TAS:ReactomePomega-hydroxylase P450 pathway
GO:0055114 TAS:UniProtKBPoxidation-reduction process
GO:0045766 ISS:UniProtKBPpositive regulation of angiogenesis
GO:0043065 ISS:UniProtKBPpositive regulation of apoptotic process
GO:1901313 ISS:UniProtKBPpositive regulation of gene expression involved in extracellular matrix organization
GO:0046427 ISS:UniProtKBPpositive regulation of JAK-STAT cascade
GO:0010575 ISS:UniProtKBPpositive regulation vascular endothelial growth factor production
GO:2000377 ISS:UniProtKBPregulation of reactive oxygen species metabolic process
GO:0009636 IEA:EnsemblPresponse to toxic substance
GO:0061304 ISS:UniProtKBPretinal blood vessel morphogenesis
GO:0042574 IDA:UniProtKBPretinal metabolic process
GO:0042572 IDA:UniProtKBPretinol metabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0008202 IDA:UniProtKBPsteroid metabolic process
GO:0016125 TAS:ReactomePsterol metabolic process
GO:0009404 IEA:EnsemblPtoxin metabolic process
GO:0002930 ISS:UniProtKBPtrabecular meshwork development
GO:0007601 TAS:UniProtKBPvisual perception
GO:0006805 IDA:UniProtKBPxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147851Arachidonic acid metabolism
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_13812Endogenous sterols
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_13705Phase 1 - Functionalization of compounds
REACT_150134Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
REACT_150417Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
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