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MGP000748

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 2, subfamily A, polypeptide 6
Protein EntryCP2A6_HUMAN
UniProt IDP11509
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.23 uM for coumarin {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:16086027}; KM=530 uM for 1,4-cineole {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:16086027}; Vmax=3.5 nmol/min/nmol enzyme toward 2-exo-hydroxy-1,4-cineole {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:16086027};
Catalytic Activity1,4-cineole + NADPH + O(2) = 2-exo-hydroxy- 1,4-cineole + NADP(+) + H(2)O. {ECO:0000269|PubMed:11695850}.
CofactorName=heme; Xref=ChEBI:CHEBI:30413;
FunctionExhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4- cineole 2-exo-monooxygenase. Possesses low phenacetin O- deethylation activity. {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:16086027, ECO:0000269|PubMed:17125252, ECO:0000269|PubMed:18779312, ECO:0000269|PubMed:1889415, ECO:0000269|PubMed:1944238}.
InductionBy phenobarbital and dexamethasone. {ECO:0000269|PubMed:1889415, ECO:0000269|PubMed:1944238}.
Sequence CautionSequence=AAA52147.1; Type=Miscellaneous discrepancy; Note=Numerous conflicts and frameshifts.; Evidence={ECO:0000305};
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue SpecificityLiver. {ECO:0000269|PubMed:1889415, ECO:0000269|PubMed:1944238}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CYP2A6ID40240ch19q13.html";
Web ResourceName=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2A6 alleles; URL="http://www.cypalleles.ki.se/cyp2a6.htm";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2a6/";
Web ResourceName=Wikipedia; Note=CYP2A6 entry; URL="http://en.wikipedia.org/wiki/CYP2A6";
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