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MGP000752

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 2, subfamily B, polypeptide 6
Protein EntryCP2B6_HUMAN
UniProt IDP20813
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P20813-1; Sequence=Displayed; Name=2; IsoId=P20813-2; Sequence=VSP_055571, VSP_055572; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=360 uM for 1,4-cineole {ECO:0000269|PubMed:11695850}; Vmax=3.4 nmol/min/nmol enzyme toward 2-exo-hydroxy-1,4-cineole {ECO:0000269|PubMed:11695850};
Catalytic Activity1,4-cineole + NADPH + O(2) = 2-exo-hydroxy- 1,4-cineole + NADP(+) + H(2)O. {ECO:0000269|PubMed:11695850}.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000269|PubMed:20061448, ECO:0000269|PubMed:21875942, ECO:0000269|PubMed:22909231};
FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase. {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:20061448, ECO:0000269|PubMed:21875942, ECO:0000269|PubMed:22909231}.
InductionBy phenobarbital.
PolymorphismGenetic variations in CYP2B6 are responsible for poor metabolism of efavirenz and, therefore, susceptibility to efavirenz toxicity in the central nervous system [MIM:614546]. Efavirenz is a non-nucleoside reverse transcriptase inhibitor frequently prescribed with 2 nucleoside reverse transcriptase inhibitors as initial therapy for human immunodeficiency virus (HIV) infection. Up to half of patients treated with efavirenz, experience side effects in the central nervous system, including dizziness, insomnia, impaired concentration, somnolence, and abnormal dreams. Severe depression, aggressive behavior, and paranoid or manic reactions may also occur, depending on efavirenz concentration in the plasma.
PtmPhosphorylation is accompanied by a decrease in enzyme activity. {ECO:0000250}.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue SpecificityExpressed in liver, lung and heart right ventricle. {ECO:0000269|PubMed:10768437}.
Web ResourceName=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2B6 alleles; URL="http://www.cypalleles.ki.se/cyp2b6.htm";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2b6/";
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