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MGP000754

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 2, subfamily C, polypeptide 8
Protein EntryCP2C8_HUMAN
UniProt IDP10632
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P10632-1; Sequence=Displayed; Name=2; IsoId=P10632-2; Sequence=VSP_043306, VSP_043307; Note=No experimental confirmation available.;
Catalytic ActivityRH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O. {ECO:0000269|PubMed:7574697}.
CautionAlternative splicing has been shown to occur but the shorter forms are believed to be non-functional. {ECO:0000305}.
CofactorName=heme; Xref=ChEBI:CHEBI:30413;
FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol). {ECO:0000269|PubMed:7574697}.
InductionBy phenobarbital.
PolymorphismCYP2C8 genetic variations may be associated with adverse effects of cerivastatin including acute rhabdomyolysis [MIM:601129].
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Web ResourceName=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2C8 alleles; URL="http://www.cypalleles.ki.se/cyp2c8.htm";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2c8/";
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