MGP Database

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MGP000757

Ontology/Pathway Information

Entrez Gene ID1565
Gene Namecytochrome P450, family 2, subfamily D, polypeptide 6
Gene Symbol CYP2D6
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005783 TAS:BHF-UCLCendoplasmic reticulum
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0005739 IDA:BHF-UCLCmitochondrion
GO:0008392 IBA:GO_CentralFarachidonic acid epoxygenase activity
GO:0070330 IEA:UniProtKB-ECFaromatase activity
GO:0008144 IDA:BHF-UCLFdrug binding
GO:0020037 IDA:UniProtKBFheme binding
GO:0005506 IEA:InterProFiron ion binding
GO:0004497 IDA:BHF-UCLFmonooxygenase activity
GO:0016491 IDA:BHF-UCLFoxidoreductase activity
GO:0016712 IBA:GO_CentralFoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825 IBA:GO_CentralFoxygen binding
GO:0008395 IBA:GO_CentralFsteroid hydroxylase activity
GO:0009822 IDA:BHF-UCLPalkaloid catabolic process
GO:0009820 IDA:BHF-UCLPalkaloid metabolic process
GO:0019369 IBA:GO_CentralParachidonic acid metabolic process
GO:0009804 IDA:BHF-UCLPcoumarin metabolic process
GO:0042737 IDA:BHF-UCLPdrug catabolic process
GO:0017144 IDA:BHF-UCLPdrug metabolic process
GO:0042738 IBA:GO_CentralPexogenous drug catabolic process
GO:0046483 IDA:BHF-UCLPheterocycle metabolic process
GO:0033076 IDA:BHF-UCLPisoquinoline alkaloid metabolic process
GO:0016098 IDA:BHF-UCLPmonoterpenoid metabolic process
GO:0051100 IDA:BHF-UCLPnegative regulation of binding
GO:0090350 IDA:BHF-UCLPnegative regulation of cellular organofluorine metabolic process
GO:0055114 IDA:BHF-UCLPoxidation-reduction process
GO:0070989 IDA:BHF-UCLPoxidative demethylation
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0008202 IMP:BHF-UCLPsteroid metabolic process
GO:0006805 TAS:BHF-UCLPxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13433Biological oxidations
REACT_13797CYP2E1 reactions
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_13814Fatty acids
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_13425Miscellaneous substrates
REACT_13705Phase 1 - Functionalization of compounds
REACT_13543Xenobiotics
SMP Pathway Links
SMP IDDescription
SMP00640Acetaminophen Metabolism Pathway
SMP00096Celecoxib Action Pathway
SMP00644Celecoxib Metabolism Pathway
SMP00424Citalopram Action Pathway
SMP00627Citalopram Metabolism Pathway
SMP00639Clomipramine Metabolism Pathway
SMP00405Codeine Action Pathway
SMP00621Codeine Metabolism Pathway
SMP00423Desipramine Action Pathway
SMP00626Desipramine Metabolism Pathway
SMP00641Doxepin Metabolism Pathway
SMP00426Fluoxetine Action Pathway
SMP00646Fluoxetine Metabolism Pathway
SMP00422Imipramine Action Pathway
SMP00625Imipramine Metabolism Pathway
SMP00408Methadone Action Pathway
SMP00624Methadone Metabolism Pathway
SMP00642Nevirapine Metabolism Pathway
SMP00471Tamoxifen Action Pathway
SMP00606Tamoxifen Metabolism Pathway
SMP00637Tramadol Metabolism Pathway
SMP00636Venlafaxine Metabolism Pathway
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