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MGP000758

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 2, subfamily E, polypeptide 1
Protein EntryCP2E1_HUMAN
UniProt IDP05181
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O. {ECO:0000269|PubMed:9348445}.
CofactorName=heme; Xref=ChEBI:CHEBI:30413;
FunctionMetabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
InductionBy ethanol and isoniazid.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Web ResourceName=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2E1 alleles; URL="http://www.cypalleles.ki.se/cyp2e1.htm";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2e1/";
Web ResourceName=Wikipedia; Note=CYP2E1 entry; URL="http://en.wikipedia.org/wiki/CYP2E1";
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