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MGP000759

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 2, subfamily F, polypeptide 1
Protein EntryCP2F1_HUMAN
UniProt IDP24903
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P24903-1; Sequence=Displayed; Name=2; IsoId=P24903-2; Sequence=VSP_055575, VSP_055576; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=0.018 mM for 3-methylindole {ECO:0000269|PubMed:10383923, ECO:0000269|PubMed:1974816}; Vmax=51.2 pmol/min/mg enzyme toward ethoxy-coumarin {ECO:0000269|PubMed:10383923, ECO:0000269|PubMed:1974816}; Vmax=24.3 pmol/min/mg enzyme toward propoxy-coumarin {ECO:0000269|PubMed:10383923, ECO:0000269|PubMed:1974816}; Vmax=22 pmol/min/mg enzyme toward pentoxy-resorufin {ECO:0000269|PubMed:10383923, ECO:0000269|PubMed:1974816}; Vmax=2.29 pmol/min/mg enzyme toward benzyloxy-resorufin {ECO:0000269|PubMed:10383923, ECO:0000269|PubMed:1974816};
Catalytic ActivityRH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O. {ECO:0000269|PubMed:10383923, ECO:0000269|PubMed:1974816, ECO:0000269|PubMed:8558432}.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
FunctionMay be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. {ECO:0000269|PubMed:1974816}.
PolymorphismEight non disease-associated alleles are known: CYP2F1*1, CYP2F1*2A, CYP2F1*2B, CYP2F1*3, CYP2F1*4, CYP2F1*5A, CYP2F1*5B and CYP2F1*6. The sequence shown corresponds to allele CYP2F1*1.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305|PubMed:10383923}; Peripheral membrane protein {ECO:0000305|PubMed:10383923}. Microsome membrane {ECO:0000269|PubMed:10383923}; Peripheral membrane protein {ECO:0000269|PubMed:10383923}.
Tissue SpecificityExpressed in lung. Rarely detected in liver and placenta. {ECO:0000269|PubMed:1974816, ECO:0000269|PubMed:8619884}.
Web ResourceName=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2F1 alleles; URL="http://www.cypalleles.ki.se/cyp2f1.htm";
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