MGP Database

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MGP000760

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 2, subfamily J, polypeptide 2
Protein EntryCP2J2_HUMAN
UniProt IDP51589
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityRH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
FunctionThis enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue SpecificityHighly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney.
Web ResourceName=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2J2 alleles; URL="http://www.cypalleles.ki.se/cyp2j2.htm";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2j2/";
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