MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000761

Ontology/Pathway Information

Entrez Gene ID1576
Gene Namecytochrome P450, family 3, subfamily A, polypeptide 4
Gene Symbol CYP3A4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0043231 TAS:ProtIncCintracellular membrane-bounded organelle
GO:0047638 IEA:UniProtKB-ECFalbendazole monooxygenase activity
GO:0034875 IDA:BHF-UCLFcaffeine oxidase activity
GO:0019899 IPI:BHF-UCLFenzyme binding
GO:0020037 IEA:InterProFheme binding
GO:0005506 IDA:BHF-UCLFiron ion binding
GO:0004497 ISS:UniProtKBFmonooxygenase activity
GO:0016491 IDA:BHF-UCLFoxidoreductase activity
GO:0016712 IEA:InterProFoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825 TAS:ProtIncFoxygen binding
GO:0050591 IEA:UniProtKB-ECFquinine 3-monooxygenase activity
GO:0005496 IDA:BHF-UCLFsteroid binding
GO:0008395 IMP:BHF-UCLFsteroid hydroxylase activity
GO:0033780 IEA:UniProtKB-ECFtaurochenodeoxycholate 6alpha-hydroxylase activity
GO:0050649 IMP:BHF-UCLFtestosterone 6-beta-hydroxylase activity
GO:0070576 IDA:BHF-UCLFvitamin D 24-hydroxylase activity
GO:0030343 IDA:BHF-UCLFvitamin D3 25-hydroxylase activity
GO:0009822 IDA:BHF-UCLPalkaloid catabolic process
GO:0008209 TAS:BHF-UCLPandrogen metabolic process
GO:0036378 IDA:GOCPcalcitriol biosynthetic process from calciol
GO:0042737 IDA:BHF-UCLPdrug catabolic process
GO:0017144 IDA:BHF-UCLPdrug metabolic process
GO:0042738 IDA:BHF-UCLPexogenous drug catabolic process
GO:0046483 IDA:BHF-UCLPheterocycle metabolic process
GO:0006629 TAS:ProtIncPlipid metabolic process
GO:0016098 IDA:BHF-UCLPmonoterpenoid metabolic process
GO:0055114 IDA:BHF-UCLPoxidation-reduction process
GO:0070989 IDA:BHF-UCLPoxidative demethylation
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006706 IMP:BHF-UCLPsteroid catabolic process
GO:0008202 IMP:BHF-UCLPsteroid metabolic process
GO:0042359 IC:BHF-UCLPvitamin D metabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264461Aflatoxin activation and detoxification
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_267633Defective ACY1 causes encephalopathy
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_13705Phase 1 - Functionalization of compounds
REACT_13543Xenobiotics
SMP Pathway Links
SMP IDDescription
SMP00640Acetaminophen Metabolism Pathway
SMP00651Artemether Metabolism Pathway
SMP00028Caffeine Metabolism
SMP00634Carbamazepine Metabolism Pathway
SMP00096Celecoxib Action Pathway
SMP00644Celecoxib Metabolism Pathway
SMP00639Clomipramine Metabolism Pathway
SMP00260Clopidogrel Action Pathway
SMP00610Clopidogrel Metabolism Pathway
SMP00405Codeine Action Pathway
SMP00621Codeine Metabolism Pathway
SMP00447Cyclophosphamide Action Pathway
SMP00604Cyclophosphamide Metabolism Pathway
SMP00641Doxepin Metabolism Pathway
SMP00442Etoposide Action Pathway
SMP00601Etoposide Metabolism Pathway
SMP00633Felbamate Metabolism Pathway
SMP00426Fluoxetine Action Pathway
SMP00646Fluoxetine Metabolism Pathway
SMP00086Ibuprofen Action Pathway
SMP00590Ibuprofen Metabolism Pathway
SMP00448Ifosfamide Action Pathway
SMP00605Ifosfamide Metabolism Pathway
SMP00422Imipramine Action Pathway
SMP00625Imipramine Metabolism Pathway
SMP00433Irinotecan Action Pathway
SMP00600Irinotecan Metabolism Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00398Lidocaine (Local Anaesthetic) Action Pathway
SMP00620Lidocaine (Local Anaesthetic) Metabolism Pathway
SMP00408Methadone Action Pathway
SMP00624Methadone Metabolism Pathway
SMP00652Mycophenolic Acid Metabolism Pathway
SMP00642Nevirapine Metabolism Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00440Prednisone Action Pathway
SMP00631Prednisone Metabolism Pathway
SMP00074Retinol Metabolism
SMP00648Sorafenib Metabolism Pathway
SMP00471Tamoxifen Action Pathway
SMP00606Tamoxifen Metabolism Pathway
SMP00443Teniposide Action Pathway
SMP00602Teniposide Metabolism Pathway
SMP00637Tramadol Metabolism Pathway
SMP00636Venlafaxine Metabolism Pathway
SMP00436Vinblastine Action Pathway
SMP00439Vinorelbine Action Pathway
SMP00336Vitamin A Deficiency
  logo