MGP Database

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MGP000762

Ontology/Pathway Information

Entrez Gene ID1577
Gene Namecytochrome P450, family 3, subfamily A, polypeptide 5
Gene Symbol CYP3A5
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0043231 TAS:ProtIncCintracellular membrane-bounded organelle
GO:0070330 IEA:UniProtKB-ECFaromatase activity
GO:0020037 IEA:InterProFheme binding
GO:0005506 IEA:InterProFiron ion binding
GO:0004497 ISS:UniProtKBFmonooxygenase activity
GO:0016491 IDA:BHF-UCLFoxidoreductase activity
GO:0019825 TAS:ProtIncFoxygen binding
GO:0009822 IDA:BHF-UCLPalkaloid catabolic process
GO:0042737 IDA:BHF-UCLPdrug catabolic process
GO:0070989 IDA:BHF-UCLPoxidative demethylation
GO:0010628 IEA:EnsemblPpositive regulation of gene expression
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0008202 TAS:ProtIncPsteroid metabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264461Aflatoxin activation and detoxification
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_267633Defective ACY1 causes encephalopathy
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_13705Phase 1 - Functionalization of compounds
REACT_13543Xenobiotics
SMP Pathway Links
SMP IDDescription
SMP00651Artemether Metabolism Pathway
SMP00634Carbamazepine Metabolism Pathway
SMP00260Clopidogrel Action Pathway
SMP00610Clopidogrel Metabolism Pathway
SMP00442Etoposide Action Pathway
SMP00601Etoposide Metabolism Pathway
SMP00426Fluoxetine Action Pathway
SMP00646Fluoxetine Metabolism Pathway
SMP00448Ifosfamide Action Pathway
SMP00605Ifosfamide Metabolism Pathway
SMP00433Irinotecan Action Pathway
SMP00600Irinotecan Metabolism Pathway
SMP00652Mycophenolic Acid Metabolism Pathway
SMP00642Nevirapine Metabolism Pathway
SMP00074Retinol Metabolism
SMP00471Tamoxifen Action Pathway
SMP00606Tamoxifen Metabolism Pathway
SMP00443Teniposide Action Pathway
SMP00602Teniposide Metabolism Pathway
SMP00336Vitamin A Deficiency
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