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MGP000764

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 4, subfamily B, polypeptide 1
Protein EntryCP4B1_HUMAN
UniProt IDP13584
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P13584-1; Sequence=Displayed; Name=2; IsoId=P13584-2; Sequence=VSP_038419;
Catalytic ActivityRH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250|UniProtKB:P51869};
FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
InductionP450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue SpecificityDetected in the liver and lung (at protein level). {ECO:0000269|PubMed:12695542}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CYP4B1ID40253ch1p33.html";
Web ResourceName=Cytochrome P450 Allele Nomenclature Committee; Note=CYP4B1 alleles; URL="http://www.cypalleles.ki.se/cyp4b1.htm";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp4b1/";
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