MGP Database

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MGP000768

Ontology/Pathway Information

Entrez Gene ID1584
Gene Namecytochrome P450, family 11, subfamily B, polypeptide 1
Gene Symbol CYP11B1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005743 TAS:BHF-UCLCmitochondrial inner membrane
GO:0005739 IDA:BHF-UCLCmitochondrion
GO:0020037 IC:BHF-UCLFheme binding
GO:0005506 IEA:InterProFiron ion binding
GO:0004507 IDA:BHF-UCLFsteroid 11-beta-monooxygenase activity
GO:0032342 IMP:UniProtKBPaldosterone biosynthetic process
GO:0006700 IDA:BHF-UCLPC21-steroid hormone biosynthetic process
GO:0032870 IEP:UniProtKBPcellular response to hormone stimulus
GO:0035865 IEP:UniProtKBPcellular response to potassium ion
GO:0034651 IMP:UniProtKBPcortisol biosynthetic process
GO:0006704 TAS:ReactomePglucocorticoid biosynthetic process
GO:0042593 TAS:BHF-UCLPglucose homeostasis
GO:0006955 TAS:BHF-UCLPimmune response
GO:0006705 TAS:ReactomePmineralocorticoid biosynthetic process
GO:0008217 IMP:BHF-UCLPregulation of blood pressure
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0008202 TAS:ReactomePsteroid metabolic process
GO:0016125 TAS:ReactomePsterol metabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_13812Endogenous sterols
REACT_11036Glucocorticoid biosynthesis
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_11057Metabolism of steroid hormones and vitamin D
REACT_13705Phase 1 - Functionalization of compounds
SMP Pathway Links
SMP IDDescription
SMP0057511-beta-hydroxylase deficiency (CYP11B1)
SMP0056617-alpha-hydroxylase deficiency (CYP17)
SMP0057621-hydroxylase deficiency (CYP21)
SMP007183-Beta-Hydroxysteroid Dehydrogenase Deficiency
SMP00373Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency
SMP00372Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia due to 17 Alpha-hydroxylase Deficiency
SMP00717Apparent mineralocorticoid excess syndrome
SMP00371Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
SMP00577Corticosterone methyl oxidase I deficiency (CMO I)
SMP00578Corticosterone methyl oxidase II deficiency - CMO II
SMP00130Steroidogenesis
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