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MGP000769

Record overview

MGPD IDMGP000769
Gene ID1585
SpeciesHomo sapiens (Human)
Gene Namecytochrome P450, family 11, subfamily B, polypeptide 2
Gene Symbol CYP11B2
SynonymsCPN2; ALDOS; CYP11B; CYP11BL; CYPXIB2; P450C18; P-450C18; P450aldo;
Alternate namescytochrome P450 11B2, mitochondrial; aldosterone synthase; aldosterone-synthesizing enzyme; cytochrome P-450Aldo; cytochrome P-450C18; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; steroid 11-beta-monooxygenase; steroid 11-beta/18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo;
Chromosome8
Map Location8q21-q22
EC Number1.14.15.4
SummaryThis gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CYP11B2

Proteins

cytochrome P450 11B2, mitochondrial precursor
Refseq ID:NP_000489
Protein GI:119829183
UniProt ID:P19099
mRNA ID:NM_000498
Length:503
RefSeq Status:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKL
QQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEAS
NLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAG
TLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFR
AIN
 
transit_peptide: 1..24
calculated_mol_wt: 2625
peptide sequence: 
MALRAKAEVCVAAPWLSLQRARAL

mat_peptide: 25..503
product: cytochrome P450 11B2, mitochondrial
calculated_mol_wt: 54953
peptide sequence: 
GTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRG
HKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFL
HALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLL
MTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYN
PQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
 
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