MGP Database

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MGP000770

Ontology/Pathway Information

Entrez Gene ID1586
Gene Namecytochrome P450, family 17, subfamily A, polypeptide 1
Gene Symbol CYP17A1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030424 IEA:EnsemblCaxon
GO:0005783 NAS:ProtIncCendoplasmic reticulum
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0005739 IEA:EnsemblCmitochondrion
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0047442 IEA:UniProtKB-ECF17-alpha-hydroxyprogesterone aldolase activity
GO:0020037 IDA:UniProtKBFheme binding
GO:0005506 IEA:InterProFiron ion binding
GO:0019825 TAS:ProtIncFoxygen binding
GO:0004508 IDA:UniProtKBFsteroid 17-alpha-monooxygenase activity
GO:0030325 IEA:EnsemblPadrenal gland development
GO:0006702 TAS:ReactomePandrogen biosynthetic process
GO:0018879 IEA:EnsemblPbiphenyl metabolic process
GO:0071236 IEA:EnsemblPcellular response to antibiotic
GO:0071371 IEA:EnsemblPcellular response to gonadotropin stimulus
GO:0071222 IEA:EnsemblPcellular response to lipopolysaccharide
GO:0018894 IEA:EnsemblPdibenzo-p-dioxin metabolic process
GO:0006704 TAS:ReactomePglucocorticoid biosynthetic process
GO:0021766 IEA:EnsemblPhippocampus development
GO:0042446 IDA:UniProtKBPhormone biosynthetic process
GO:0033327 IEA:EnsemblPLeydig cell differentiation
GO:0030728 IEA:EnsemblPovulation
GO:0018958 IEA:EnsemblPphenol-containing compound metabolic process
GO:0018963 IEA:EnsemblPphthalate metabolic process
GO:0090031 IEA:EnsemblPpositive regulation of steroid hormone biosynthetic process
GO:0042448 IDA:UniProtKBPprogesterone metabolic process
GO:0010034 IEA:EnsemblPresponse to acetate
GO:0051591 IEA:EnsemblPresponse to cAMP
GO:0034097 IEA:EnsemblPresponse to cytokine
GO:0042493 IEA:EnsemblPresponse to drug
GO:0060992 IEA:EnsemblPresponse to fungicide
GO:0009635 IEA:EnsemblPresponse to herbicide
GO:0017085 IEA:EnsemblPresponse to insecticide
GO:0010212 IEA:EnsemblPresponse to ionizing radiation
GO:0051597 IEA:EnsemblPresponse to methylmercury
GO:0031667 IEA:EnsemblPresponse to nutrient levels
GO:0032526 IEA:EnsemblPresponse to retinoic acid
GO:0048545 IEA:EnsemblPresponse to steroid hormone
GO:0007548 TAS:ProtIncPsex differentiation
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006694 TAS:ProtIncPsteroid biosynthetic process
GO:0008202 IDA:UniProtKBPsteroid metabolic process
GO:0016125 TAS:ReactomePsterol metabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_11059Androgen biosynthesis
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_13812Endogenous sterols
REACT_11036Glucocorticoid biosynthesis
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_11057Metabolism of steroid hormones and vitamin D
REACT_13705Phase 1 - Functionalization of compounds
SMP Pathway Links
SMP IDDescription
SMP0057511-beta-hydroxylase deficiency (CYP11B1)
SMP0056617-alpha-hydroxylase deficiency (CYP17)
SMP0035617-Beta Hydroxysteroid Dehydrogenase III Deficiency
SMP0057621-hydroxylase deficiency (CYP21)
SMP007183-Beta-Hydroxysteroid Dehydrogenase Deficiency
SMP00373Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency
SMP00372Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia due to 17 Alpha-hydroxylase Deficiency
SMP00068Androgen and Estrogen Metabolism
SMP00717Apparent mineralocorticoid excess syndrome
SMP00565Aromatase deficiency
SMP00371Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
SMP00577Corticosterone methyl oxidase I deficiency (CMO I)
SMP00578Corticosterone methyl oxidase II deficiency - CMO II
SMP00130Steroidogenesis
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