MGP Database

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MGP000776

Ontology/Pathway Information

Entrez Gene ID1594
Gene Namecytochrome P450, family 27, subfamily B, polypeptide 1
Gene Symbol CYP27B1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0005741 TAS:ReactomeCmitochondrial outer membrane
GO:0005739 ISS:BHF-UCLCmitochondrion
GO:0004498 IDA:BHF-UCLFcalcidiol 1-monooxygenase activity
GO:0020037 IEA:InterProFheme binding
GO:0005506 IEA:InterProFiron ion binding
GO:0030282 IEP:BHF-UCLPbone mineralization
GO:0036378 IDA:BHF-UCLPcalcitriol biosynthetic process from calciol
GO:0055074 IMP:BHF-UCLPcalcium ion homeostasis
GO:0006816 ISS:BHF-UCLPcalcium ion transport
GO:0046697 IEP:BHF-UCLPdecidualization
GO:0070314 IMP:BHF-UCLPG1 to G0 transition
GO:0010956 IDA:BHF-UCLPnegative regulation of calcidiol 1-monooxygenase activity
GO:0030308 IMP:BHF-UCLPnegative regulation of cell growth
GO:0008285 IDA:BHF-UCLPnegative regulation of cell proliferation
GO:0045618 IMP:BHF-UCLPpositive regulation of keratinocyte differentiation
GO:0010980 IDA:BHF-UCLPpositive regulation of vitamin D 24-hydroxylase activity
GO:0070564 IDA:BHF-UCLPpositive regulation of vitamin D receptor signaling pathway
GO:0030500 IMP:BHF-UCLPregulation of bone mineralization
GO:0043627 IEP:BHF-UCLPresponse to estrogen
GO:0034341 IDA:BHF-UCLPresponse to interferon-gamma
GO:0032496 IDA:BHF-UCLPresponse to lipopolysaccharide
GO:0033280 IDA:BHF-UCLPresponse to vitamin D
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0008202 TAS:ReactomePsteroid metabolic process
GO:0042369 IEA:EnsemblPvitamin D catabolic process
GO:0042359 IDA:BHF-UCLPvitamin D metabolic process
GO:0006766 TAS:ReactomePvitamin metabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_11057Metabolism of steroid hormones and vitamin D
REACT_13705Phase 1 - Functionalization of compounds
REACT_13523Vitamin D (calciferol) metabolism
REACT_13450Vitamins
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