MGP Database

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MGP000777

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 51, subfamily A, polypeptide 1
Protein EntryCP51A_HUMAN
UniProt IDQ16850
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16850-1; Sequence=Displayed; Name=2; IsoId=Q16850-2; Sequence=VSP_037413; Note=No experimental confirmation available.;
Catalytic ActivityA 14-alpha-methylsteroid + 3 O(2) + 3 NADPH = a Delta(14)-steroid + formate + 3 NADP(+) + 4 H(2)O. {ECO:0000269|PubMed:20149798}.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000269|PubMed:20149798};
FunctionCatalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. {ECO:0000269|PubMed:20149798}.
PathwaySteroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.
Sequence CautionSequence=AAB39951.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAB46356.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH32322.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA09512.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG36881.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAL24154.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW76858.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}. Microsome membrane {ECO:0000305}.
Tissue SpecificityUbiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung. {ECO:0000269|PubMed:8619637}.
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