MGP Database

MGP000778

Ontology/Pathway Information

Entrez Gene ID	1601
Gene Name	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Gene Symbol	DAB2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0016324	IEA:Ensembl	C	apical plasma membrane
GO:0030136	IDA:UniProtKB	C	clathrin-coated vesicle
GO:0030665	IEA:UniProtKB-SubCell	C	clathrin-coated vesicle membrane
GO:0030132	IEA:Ensembl	C	clathrin coat of coated pit
GO:0005905	IDA:UniProtKB	C	coated pit
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0005925	IDA:UniProtKB	C	focal adhesion
GO:0043231	IDA:HPA	C	intracellular membrane-bounded organelle
GO:0005765	TAS:Reactome	C	lysosomal membrane
GO:0005730	IDA:HPA	C	nucleolus
GO:0005886	IDA:HPA	C	plasma membrane
GO:0038024	IMP:UniProtKB	F	cargo receptor activity
GO:0035615	IMP:UniProtKB	F	clathrin adaptor activity
GO:0005546	IEA:Ensembl	F	phosphatidylinositol-4,5-bisphosphate binding
GO:0008022	IPI:UniProtKB	F	protein C-terminus binding
GO:0046332	IDA:UniProtKB	F	SMAD binding
GO:0007257	IEA:Ensembl	P	activation of JUN kinase activity
GO:0006915	IEA:UniProtKB-KW	P	apoptotic process
GO:0000904	IEA:Ensembl	P	cell morphogenesis involved in differentiation
GO:0008283	TAS:ProtInc	P	cell proliferation
GO:0071560	IEA:Ensembl	P	cellular response to transforming growth factor beta stimulus
GO:0048268	IEA:Ensembl	P	clathrin coat assembly
GO:0007492	IEA:Ensembl	P	endoderm development
GO:0007588	IEA:Ensembl	P	excretion
GO:0001701	IEA:Ensembl	P	in utero embryonic development
GO:0035026	IMP:UniProtKB	P	leading edge cell differentiation
GO:0061024	TAS:Reactome	P	membrane organization
GO:0030099	IEA:Ensembl	P	myeloid cell differentiation
GO:0060766	IMP:UniProtKB	P	negative regulation of androgen receptor signaling pathway
GO:0043066	IDA:UniProtKB	P	negative regulation of apoptotic process
GO:0090090	IMP:BHF-UCL	P	negative regulation of canonical Wnt signaling pathway
GO:2001237	IEA:Ensembl	P	negative regulation of extrinsic apoptotic signaling pathway
GO:0032091	IMP:BHF-UCL	P	negative regulation of protein binding
GO:1903077	IMP:UniProtKB	P	negative regulation of protein localization to plasma membrane
GO:0045892	IMP:BHF-UCL	P	negative regulation of transcription, DNA-templated
GO:0006907	IEA:Ensembl	P	pinocytosis
GO:0030335	IMP:UniProtKB	P	positive regulation of cell migration
GO:2000370	IMP:UniProtKB	P	positive regulation of clathrin-mediated endocytosis
GO:2000643	IMP:UniProtKB	P	positive regulation of early endosome to late endosome transport
GO:0045807	IMP:UniProtKB	P	positive regulation of endocytosis
GO:0010718	IDA:UniProtKB	P	positive regulation of epithelial to mesenchymal transition
GO:2001046	IEA:Ensembl	P	positive regulation of integrin-mediated signaling pathway
GO:0010862	IDA:UniProtKB	P	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0032436	IMP:BHF-UCL	P	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001934	IMP:BHF-UCL	P	positive regulation of protein phosphorylation
GO:0001921	IEA:Ensembl	P	positive regulation of receptor recycling
GO:0060391	IDA:UniProtKB	P	positive regulation of SMAD protein import into nucleus
GO:1900026	IEA:Ensembl	P	positive regulation of substrate adhesion-dependent cell spreading
GO:0045893	IMP:BHF-UCL	P	positive regulation of transcription, DNA-templated
GO:0032968	IEA:Ensembl	P	positive regulation of transcription elongation from RNA polymerase II promoter
GO:0030511	IDA:UniProtKB	P	positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000096	IMP:BHF-UCL	P	positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:0015031	IEA:UniProtKB-KW	P	protein transport
GO:0006898	IMP:GOC	P	receptor-mediated endocytosis
GO:0016055	IEA:UniProtKB-KW	P	Wnt signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_11049	Formation of annular gap junctions
REACT_11035	Gap junction degradation
REACT_9411	Gap junction trafficking
REACT_9480	Gap junction trafficking and regulation
REACT_11123	Membrane Trafficking