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MGP Database

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MGP000784

UniProt Annotations

Entry Information

Gene Name	diacylglycerol kinase, gamma 90kDa
Protein Entry	DGKG_HUMAN
UniProt ID	P49619
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=P49619-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P49619-2; Sequence=VSP_001267; Note=May be inactive.; Name=3; IsoId=P49619-3; Sequence=VSP_039922;
Catalytic Activity	ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Enzyme Regulation	Requires phosphatidylserine for maximal activity.
Function	Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid.
Similarity	Belongs to the eukaryotic diacylglycerol kinase family. {ECO:0000305}.
Similarity	Contains 1 DAGKc domain. {ECO:0000255\|PROSITE- ProRule:PRU00783}.
Similarity	Contains 2 EF-hand domains. {ECO:0000255\|PROSITE- ProRule:PRU00448}.
Similarity	Contains 2 phorbol-ester/DAG-type zinc fingers. {ECO:0000255\|PROSITE-ProRule:PRU00226}.
Subcellular Location	Cytoplasm. Membrane. Note=Can be loosely bound to the membranes.
Tissue Specificity	Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma.