MGP Database

MGP000790

Ontology/Pathway Information

Entrez Gene ID	1621
Gene Name	dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Gene Symbol	DBH
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0034466	IEA:UniProtKB-SubCell	C	chromaffin granule lumen
GO:0042584	IEA:UniProtKB-SubCell	C	chromaffin granule membrane
GO:0005737	TAS:ProtInc	C	cytoplasm
GO:0005576	NAS:UniProtKB	C	extracellular region
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0016020	TAS:ProtInc	C	membrane
GO:0034774	TAS:Reactome	C	secretory granule lumen
GO:0030658	IEA:UniProtKB-SubCell	C	transport vesicle membrane
GO:0003824	TAS:ProtInc	F	catalytic activity
GO:0005507	IEA:InterPro	F	copper ion binding
GO:0004500	TAS:Reactome	F	dopamine beta-monooxygenase activity
GO:0031418	IEA:UniProtKB-KW	F	L-ascorbic acid binding
GO:0048149	IEA:Ensembl	P	behavioral response to ethanol
GO:0001974	IEA:Ensembl	P	blood vessel remodeling
GO:0042423	TAS:Reactome	P	catecholamine biosynthetic process
GO:0034641	TAS:Reactome	P	cellular nitrogen compound metabolic process
GO:0001816	IEA:Ensembl	P	cytokine production
GO:0042420	IEA:Ensembl	P	dopamine catabolic process
GO:0042596	IEA:Ensembl	P	fear response
GO:0042593	IEA:Ensembl	P	glucose homeostasis
GO:0042309	IEA:Ensembl	P	homoiothermy
GO:0002443	IEA:Ensembl	P	leukocyte mediated immunity
GO:0050900	IEA:Ensembl	P	leukocyte migration
GO:0007626	IEA:Ensembl	P	locomotory behavior
GO:0042711	IEA:Ensembl	P	maternal behavior
GO:0007613	IEA:Ensembl	P	memory
GO:0042421	IEA:UniProtKB-UniPathway	P	norepinephrine biosynthetic process
GO:0045907	IEA:Ensembl	P	positive regulation of vasoconstriction
GO:0042127	IEA:Ensembl	P	regulation of cell proliferation
GO:2001236	IEA:Ensembl	P	regulation of extrinsic apoptotic signaling pathway
GO:0001975	IEA:Ensembl	P	response to amphetamine
GO:0048265	IEA:Ensembl	P	response to pain
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0007268	TAS:ProtInc	P	synaptic transmission
GO:0008542	IEA:Ensembl	P	visual learning

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_15513	Amine-derived hormones
REACT_15551	Catecholamine biosynthesis
REACT_111217	Metabolism
REACT_13	Metabolism of amino acids and derivatives

SMP Pathway Links

SMP ID	Description
SMP00169	Alkaptonuria
SMP00170	Aromatic L-Aminoacid Decarboxylase Deficiency
SMP00012	Catecholamine Biosynthesis
SMP00429	Disulfiram Action Pathway
SMP00498	Dopamine beta-hydroxylase deficiency
SMP00190	Hawkinsinuria
SMP00533	Monoamine oxidase-a deficiency (MAO-A)
SMP00497	Tyrosine hydroxylase deficiency
SMP00006	Tyrosine Metabolism
SMP00494	Tyrosinemia, transient, of the newborn
SMP00218	Tyrosinemia Type I