MGP Database

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MGP000798

Ontology/Pathway Information

Entrez Gene ID1636
Gene Nameangiotensin I converting enzyme
Gene Symbol ACE
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005768 IDA:BHF-UCLCendosome
GO:0009897 IDA:BHF-UCLCexternal side of plasma membrane
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0003779 IDA:UniProtKBFactin binding
GO:0031711 IPI:BHF-UCLFbradykinin receptor binding
GO:0004180 IEA:UniProtKB-KWFcarboxypeptidase activity
GO:0031404 IDA:BHF-UCLFchloride ion binding
GO:0008144 IDA:BHF-UCLFdrug binding
GO:0004175 IDA:UniProtKBFendopeptidase activity
GO:0008237 IDA:UniProtKBFmetallopeptidase activity
GO:0008241 IDA:UniProtKBFpeptidyl-dipeptidase activity
GO:0008270 IDA:BHF-UCLFzinc ion binding
GO:0002005 IC:UniProtKBPangiotensin catabolic process in blood
GO:0002003 TAS:ReactomePangiotensin maturation
GO:0050482 IDA:BHF-UCLParachidonic acid secretion
GO:0001974 IC:BHF-UCLPblood vessel remodeling
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0060218 IC:BHF-UCLPhematopoietic stem cell differentiation
GO:0042447 IDA:BHF-UCLPhormone catabolic process
GO:0001822 IMP:BHF-UCLPkidney development
GO:0032943 IC:BHF-UCLPmononuclear cell proliferation
GO:0043171 IDA:BHF-UCLPpeptide catabolic process
GO:0008217 ISS:BHF-UCLPregulation of blood pressure
GO:0002019 IC:BHF-UCLPregulation of renal output by angiotensin
GO:0014910 ISS:BHF-UCLPregulation of smooth muscle cell migration
GO:0003081 IC:UniProtKBPregulation of systemic arterial blood pressure by renin-angiotensin
GO:0019229 IC:UniProtKBPregulation of vasoconstriction
GO:0042312 IC:BHF-UCLPregulation of vasodilation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147707Metabolism of Angiotensinogen to Angiotensins
REACT_17015Metabolism of proteins
REACT_160078Peptide hormone metabolism
SMP Pathway Links
SMP IDDescription
SMP00587Angiotensin Metabolism
SMP00145Benazepril Action Pathway
SMP00591Benazepril Metabolism Pathway
SMP00158Candesartan Action Pathway
SMP00146Captopril Action Pathway
SMP00147Cilazapril Action Pathway
SMP00592Cilazapril Metabolism Pathway
SMP00148Enalapril Action Pathway
SMP00593Enalapril Metabolism Pathway
SMP00159Eprosartan Action Pathway
SMP00160Forasartan Action Pathway
SMP00149Fosinopril Action Pathway
SMP00594Fosinopril Metabolism Pathway
SMP00161Irbesartan Action Pathway
SMP00150Lisinopril Action Pathway
SMP00162Losartan Action Pathway
SMP00151Moexipril Action Pathway
SMP00595Moexipril Metabolism Pathway
SMP00163Olmesartan Action Pathway
SMP00152Perindopril Action Pathway
SMP00153Quinapril Action Pathway
SMP00596Quinapril Metabolism Pathway
SMP00154Ramipril Action Pathway
SMP00597Ramipril Metabolism Pathway
SMP00155Rescinnamine Action Pathway
SMP00156Spirapril Action Pathway
SMP00598Spirapril Metabolism Pathway
SMP00164Telmisartan Action Pathway
SMP00733Temocapril Action Pathway
SMP00732Temocapril Metabolism Pathway
SMP00157Trandolapril Action Pathway
SMP00599Trandolapril Metabolism Pathway
SMP00165Valsartan Action Pathway
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