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MGP000799

UniProt Annotations

Entry Information
Gene Namedopachrome tautomerase
Protein EntryTYRP2_HUMAN
UniProt IDP40126
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P40126-1; Sequence=Displayed; Name=2; Synonyms=TRP-2-6b; IsoId=P40126-2; Sequence=VSP_043581;
Catalytic ActivityL-dopachrome = 5,6-dihydroxyindole-2- carboxylate.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
FunctionInvolved in regulating eumelanin and phaeomelanin levels.
PathwayPigment biosynthesis; melanin biosynthesis.
SimilarityBelongs to the tyrosinase family. {ECO:0000305}.
Subcellular LocationMelanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Single-pass type I membrane protein {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}.
SubunitTyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex. {ECO:0000250}.
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