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MGP000805

UniProt Annotations

Entry Information
Gene Namealdo-keto reductase family 1, member C1
Protein EntryAK1C1_HUMAN
UniProt IDQ04828
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=5 uM for (s)-tetralol {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}; KM=38 uM for (s)-indan-1-ol {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}; KM=580 uM for benzene dihydrodiol {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}; KM=3 uM for 5-beta-pregnane-3-alpha,20-alpha-diol {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}; KM=3 uM for 5-beta-pregnan-20-alpha-ol-3-one {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}; KM=12 uM for 4-pregnen-20-alpha-ol-3-one {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}; KM=133 uM for 9-alpha,11-beta-PGF2 {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}; KM=2 uM for 5-beta-pregnan-3-alpha-ol-20-one {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}; KM=1 uM for 5-beta-androstane-3,17-dione {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}; KM=12 uM for PGD2 {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}; KM=0.6 uM for 20-alpha-hydroxyprogesterone (with NADH) {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067};
Catalytic Activity17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha-hydroxyprogesterone + NAD(P)H.
Catalytic ActivityIndan-1-ol + NAD(P)(+) = indanone + NAD(P)H.
Catalytic ActivityTrans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
Enzyme RegulationInhibited by hexestrol with an IC(50) of 9.5 uM, 1,10-phenanthroline with an IC(50) of 55 uM, 1,7- phenanthroline with an IC(50) of 72 uM, flufenamic acid with an IC(50) of 6.0 uM, indomethacin with an IC(50) of 140 uM, ibuprofen with an IC(50) of 950 uM, lithocholic acid with an IC(50) of 25 uM, ursodeoxycholic acid with an IC(50) of 340 uM and chenodeoxycholic acid with an IC(50) of 570 uM. {ECO:0000269|PubMed:8573067}.
FunctionConverts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}.
SimilarityBelongs to the aldo/keto reductase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitMonomer. {ECO:0000269|PubMed:12899831, ECO:0000269|PubMed:21414777}.
Tissue SpecificityExpressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain. {ECO:0000269|PubMed:11013348}.
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