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MGP000821

Record overview

MGPD IDMGP000821
Gene ID1675
SpeciesHomo sapiens (Human)
Gene Namecomplement factor D (adipsin)
Gene Symbol CFD
SynonymsDF; ADN; PFD; ADIPSIN;
Alternate namescomplement factor D; properdin factor D; C3 convertase activator; complement factor D preproprotein; D component of complement (adipsin);
Chromosome19
Map Location19p13.3
EC Number3.4.21.46
SummaryThe protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CFD

Proteins

complement factor D preproprotein
Refseq ID:NP_001919
Protein GI:42544239
UniProt ID:P00746
mRNA ID:NM_001928
Length:253
RefSeq Status:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRA
VPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNR
RDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
 
sig_peptide: 1..20
calculated_mol_wt: 2083
peptide sequence: 
MHSWERLAVLVLLGAAACAA

mat_peptide: 26..253
product: complement factor D
calculated_mol_wt: 24405
peptide sequence: 
ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKAT
LGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSG
SRVCGNRKKPGIYTRVASYAAWIDSVLA
 
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