MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000822

UniProt Annotations

Entry Information
Gene NameDNA fragmentation factor, 45kDa, alpha polypeptide
Protein EntryDFFA_HUMAN
UniProt IDO00273
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=DFF45; IsoId=O00273-1; Sequence=Displayed; Name=DFF35; IsoId=O00273-2; Sequence=VSP_001085, VSP_001086;
FunctionInhibitor of the caspase-activated DNase (DFF40).
InteractionO54788:Dffb (xeno); NbExp=8; IntAct=EBI-727171, EBI-7365197; P04792:HSPB1; NbExp=2; IntAct=EBI-727171, EBI-352682;
PtmCaspase-3 cleaves DFF45 at 2 sites to generate an active factor.
SimilarityContains 1 CIDE-N domain. {ECO:0000255|PROSITE- ProRule:PRU00447}.
Subcellular LocationCytoplasm.
SubunitHeterodimer of DFFA and DFFB.
  logo