MGP Database

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MGP000839

Ontology/Pathway Information

Entrez Gene ID1739
Gene Namediscs, large homolog 1 (Drosophila)
Gene Symbol DLG1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005605 IEA:EnsemblCbasal lamina
GO:0016323 IDA:UniProtKBCbasolateral plasma membrane
GO:0005911 IDA:UniProtKBCcell-cell junction
GO:0030054 IDA:UniProtKBCcell junction
GO:0031253 IEA:EnsemblCcell projection membrane
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0009898 IDA:UniProtKBCcytoplasmic side of plasma membrane
GO:0005829 TAS:ReactomeCcytosol
GO:0005783 IDA:UniProtKBCendoplasmic reticulum
GO:0005789 IEA:UniProtKB-SubCellCendoplasmic reticulum membrane
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005794 IDA:UniProtKBCGolgi apparatus
GO:0001772 TAS:BHF-UCLCimmunological synapse
GO:0014704 TAS:BHF-UCLCintercalated disc
GO:0043219 IEA:EnsemblClateral loop
GO:0016328 IEA:EnsemblClateral plasma membrane
GO:0045121 IEA:EnsemblCmembrane raft
GO:0005874 IDA:UniProtKBCmicrotubule
GO:0097025 IDA:BHF-UCLCMPP7-DLG1-LIN7 complex
GO:0035748 IEA:EnsemblCmyelin sheath abaxonal region
GO:0031594 IEA:EnsemblCneuromuscular junction
GO:0033268 IEA:EnsemblCnode of Ranvier
GO:0005634 IDA:BHF-UCLCnucleus
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0005886 TAS:ReactomeCplasma membrane
GO:0014069 IEA:UniProtKB-SubCellCpostsynaptic density
GO:0045211 IEA:UniProtKB-KWCpostsynaptic membrane
GO:0042383 IEA:UniProtKB-SubCellCsarcolemma
GO:0005923 IDA:BHF-UCLCtight junction
GO:0008092 TAS:ProtIncFcytoskeletal protein binding
GO:0004385 TAS:ProtIncFguanylate kinase activity
GO:0044325 IPI:BHF-UCLFion channel binding
GO:0097016 IPI:BHF-UCLFL27 domain binding
GO:0031434 IPI:UniProtKBFmitogen-activated protein kinase kinase binding
GO:0019902 IPI:UniProtKBFphosphatase binding
GO:0004721 TAS:UniProtKBFphosphoprotein phosphatase activity
GO:0015459 NAS:UniProtKBFpotassium channel regulator activity
GO:0008022 IPI:UniProtKBFprotein C-terminus binding
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0007015 IDA:UniProtKBPactin filament organization
GO:0032147 IEA:EnsemblPactivation of protein kinase activity
GO:0042982 IEA:EnsemblPamyloid precursor protein metabolic process
GO:0007411 TAS:ReactomePaxon guidance
GO:0001658 IEA:EnsemblPbranching involved in ureteric bud morphogenesis
GO:0030866 IDA:UniProtKBPcortical actin cytoskeleton organization
GO:0016311 TAS:GOCPdephosphorylation
GO:0048704 IEA:EnsemblPembryonic skeletal system morphogenesis
GO:0001935 IDA:UniProtKBPendothelial cell proliferation
GO:0007163 TAS:UniProtKBPestablishment or maintenance of cell polarity
GO:0060022 IEA:EnsemblPhard palate development
GO:0001771 IEA:EnsemblPimmunological synapse formation
GO:0002088 IEA:EnsemblPlens development in camera-type eye
GO:0031579 IEA:EnsemblPmembrane raft organization
GO:0007093 NAS:UniProtKBPmitotic cell cycle checkpoint
GO:0050680 IEA:EnsemblPnegative regulation of epithelial cell proliferation
GO:0045930 IMP:UniProtKBPnegative regulation of mitotic cell cycle
GO:0051898 IEA:EnsemblPnegative regulation of protein kinase B signaling
GO:0042130 IEA:EnsemblPnegative regulation of T cell proliferation
GO:0046939 TAS:GOCPnucleotide phosphorylation
GO:0030432 IEA:EnsemblPperistalsis
GO:0030838 IEA:EnsemblPpositive regulation of actin filament polymerization
GO:0008284 IEA:EnsemblPpositive regulation of cell proliferation
GO:0090004 IDA:BHF-UCLPpositive regulation of establishment of protein localization to plasma membrane
GO:0043268 IDA:BHF-UCLPpositive regulation of potassium ion transport
GO:0072659 IMP:BHF-UCLPprotein localization to plasma membrane
GO:0042391 IDA:BHF-UCLPregulation of membrane potential
GO:0031641 IEA:EnsemblPregulation of myelination
GO:1902305 TAS:BHF-UCLPregulation of sodium ion transmembrane transport
GO:0048608 IEA:EnsemblPreproductive structure development
GO:0016337 IDA:UniProtKBPsingle organismal cell-cell adhesion
GO:0048745 IEA:EnsemblPsmooth muscle tissue development
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0042110 IEA:EnsemblPT cell activation
GO:0002369 IEA:EnsemblPT cell cytokine production
GO:0070830 IDA:BHF-UCLPtight junction assembly
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_21346Activation of Ca-permeable Kainate Receptor
REACT_21312Activation of Kainate Receptors upon glutamate binding
REACT_18266Axon guidance
REACT_111045Developmental Biology
REACT_18347Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
REACT_21322Ionotropic activity of Kainate Receptors
REACT_22205L1CAM interactions
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_22329NrCAM interactions
REACT_18307Trafficking of AMPA receptors
REACT_13477Transmission across Chemical Synapses
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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