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MGP000846

UniProt Annotations

Entry Information
Gene Namedynamin 1
Protein EntryDYN1_HUMAN
UniProt IDQ05193
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q05193-1; Sequence=Displayed; Name=2; IsoId=Q05193-2; Sequence=VSP_031518; Name=3; IsoId=Q05193-3; Sequence=VSP_031519; Name=4; IsoId=Q05193-4; Sequence=VSP_031520; Name=5; IsoId=Q05193-5; Sequence=VSP_031518, VSP_031519;
Catalytic ActivityGTP + H(2)O = GDP + phosphate.
FunctionMicrotubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
InteractionSelf; NbExp=7; IntAct=EBI-713135, EBI-713135; P68135:ACTA1 (xeno); NbExp=5; IntAct=EBI-8446026, EBI-367540; Q96RU3:FNBP1; NbExp=5; IntAct=EBI-713135, EBI-1111248; P62993:GRB2; NbExp=3; IntAct=EBI-713135, EBI-401755; P42858:HTT; NbExp=3; IntAct=EBI-713135, EBI-466029; Q5S007:LRRK2; NbExp=4; IntAct=EBI-713135, EBI-5323863; P16333:NCK1; NbExp=2; IntAct=EBI-713135, EBI-389883; Q8IVI9:NOSTRIN; NbExp=3; IntAct=EBI-713135, EBI-1391643;
SimilarityBelongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. {ECO:0000305}.
SimilarityContains 1 dynamin-type G (guanine nucleotide-binding) domain. {ECO:0000305}.
SimilarityContains 1 GED domain. {ECO:0000255|PROSITE- ProRule:PRU00720}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:15703209}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15703209}. Note=Microtubule-associated.
SubunitInteracts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3 domain). Interacts with SNX33 (via SH3 domain). Interacts with UNC119; leading to a decrease of DNM1 GTPase activity (By similarity). {ECO:0000250}.
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