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MGP000852

UniProt Annotations

Entry Information
Gene Namedynein, cytoplasmic 1, light intermediate chain 2
Protein EntryDC1L2_HUMAN
UniProt IDO43237
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43237-1; Sequence=Displayed; Name=2; IsoId=O43237-2; Sequence=VSP_054663; Note=No experimental confirmation available.;
FunctionActs as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
SimilarityBelongs to the dynein light intermediate chain family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytoskeleton {ECO:0000250}.
SubunitHomodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1 (By similarity). {ECO:0000250}.
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