MGP Database

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MGP000854

Ontology/Pathway Information

Entrez Gene ID1786
Gene NameDNA (cytosine-5-)-methyltransferase 1
Gene Symbol DNMT1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005634 TAS:ProtIncCnucleus
GO:0005721 IEA:EnsemblCpericentric heterochromatin
GO:0005657 IEA:EnsemblCreplication fork
GO:0003682 IEA:EnsemblFchromatin binding
GO:0003677 IDA:UniProtKBFDNA binding
GO:0003886 IDA:UniProtKBFDNA (cytosine-5-)-methyltransferase activity
GO:0009008 IDA:UniProtKBFDNA-methyltransferase activity
GO:0008327 IEA:EnsemblFmethyl-CpG binding
GO:0003723 IEA:EnsemblFRNA binding
GO:0008270 IEA:EnsemblFzinc ion binding
GO:0071230 IEA:EnsemblPcellular response to amino acid stimulus
GO:0016568 IEA:UniProtKB-KWPchromatin modification
GO:0006306 TAS:ProtIncPDNA methylation
GO:0016458 IEA:EnsemblPgene silencing
GO:0010216 IDA:UniProtKBPmaintenance of DNA methylation
GO:0051573 IMP:UniProtKBPnegative regulation of histone H3-K9 methylation
GO:0000122 TAS:ProtIncPnegative regulation of transcription from RNA polymerase II promoter
GO:0010628 IMP:UniProtKBPpositive regulation of gene expression
GO:0051571 IMP:UniProtKBPpositive regulation of histone H3-K4 methylation
GO:0042127 IEA:EnsemblPregulation of cell proliferation
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_268237DNA methylation
REACT_264098Epigenetic regulation of gene expression
REACT_71Gene Expression
REACT_264000Negative epigenetic regulation of rRNA expression
REACT_263965NoRC negatively regulates rRNA expression
REACT_264352PRC2 methylates histones and DNA
SMP Pathway Links
SMP IDDescription
SMP00177Cystathionine Beta-Synthase Deficiency
SMP00222Glycine N-methyltransferase Deficiency
SMP00570Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type
SMP00341Hypermethioninemia
SMP00221Methionine Adenosyltransferase Deficiency
SMP00033Methionine Metabolism
SMP00340Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
SMP00214S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
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