MGP Database

MGP000855

Ontology/Pathway Information

Entrez Gene ID	1788
Gene Name	DNA (cytosine-5-)-methyltransferase 3 alpha
Gene Symbol	DNMT3A
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0000775	IEA:Ensembl	C	chromosome, centromeric region
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0000791	IDA:UniProtKB	C	euchromatin
GO:0005720	IEA:Ensembl	C	nuclear heterochromatin
GO:0016363	IDA:UniProtKB	C	nuclear matrix
GO:0005634	IDA:UniProtKB	C	nucleus
GO:0003682	IEA:Ensembl	F	chromatin binding
GO:0003677	IDA:UniProtKB	F	DNA binding
GO:0003886	IDA:UniProtKB	F	DNA (cytosine-5-)-methyltransferase activity
GO:0051718	IEA:Ensembl	F	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
GO:0042802	IPI:IntAct	F	identical protein binding
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0045322	IEA:Ensembl	F	unmethylated CpG binding
GO:0090116	IDA:GOC	P	C-5 methylation of cytosine
GO:0071230	IEA:Ensembl	P	cellular response to amino acid stimulus
GO:0006306	IDA:UniProtKB	P	DNA methylation
GO:0043045	IEA:Ensembl	P	DNA methylation involved in embryo development
GO:0043046	IEA:Ensembl	P	DNA methylation involved in gamete generation
GO:0010424	IEA:Ensembl	P	DNA methylation on cytosine within a CG sequence
GO:0044027	IEA:Ensembl	P	hypermethylation of CpG island
GO:0006346	IEA:Ensembl	P	methylation-dependent chromatin silencing
GO:0000122	IEA:Ensembl	P	negative regulation of transcription from RNA polymerase II promoter
GO:0006349	TAS:UniProtKB	P	regulation of gene expression by genetic imprinting
GO:0046498	IEA:Ensembl	P	S-adenosylhomocysteine metabolic process
GO:0046499	IEA:Ensembl	P	S-adenosylmethioninamine metabolic process
GO:0007283	IEA:Ensembl	P	spermatogenesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_264165	Chromatin modifying enzymes
REACT_264155	Chromatin organization
REACT_268237	DNA methylation
REACT_264098	Epigenetic regulation of gene expression
REACT_71	Gene Expression
REACT_264352	PRC2 methylates histones and DNA
REACT_264545	RMTs methylate histone arginines